Ikerbasque Research Associate
Ramón y Cajal (RyC) Programme - Ikerbasque Research Associate
June Ereño-Orbea obtained her BSc in Biochemistry and a MSc in Molecular Biology & Biomedicine from the University of Basque Country (UPV/EHU) and continued her scientific pursuits by completing her PhD in Molecular Biology and Biomedicine from the same institution.
In 2015, Dr. Ereño-Orbea joined the laboratory of Dr. Julien at SickKids Hospital (Canada). In her postdoctoral research she characterized the structure of CD22 (Siglec-2), a key inhibitory co-receptor of B cells and a significant immunotherapeutic target. This research illuminated the interactions between CD22 and sialic acid glycans and provided insights into its spatial organization within B cells. The findings contributed to advancements in antibody-based therapies, specifically CAR-T cells for B-cell lymphoma treatment. Additionally, Dr. Ereño collaborated on HIV vaccine design with The Scripps Research Institute (USA).
In 2019, Dr. Ereño-Orbea joined CIC bioGUNE and completed a successful 5-year tenure-track period as an Ikerbasque Research Fellow (2019-2023). In 2024, she got promoted to Ikerbasque Research Associate and Associated Principal Investigator to lead her independent research. Her research is focused on unraveling molecular mechanisms of antibodies and lectins, particularly exploring Siglec glycoimmune checkpoint receptors for next-generation therapies in diseases like cancer. Using integrative molecular and structural biology and biophysical techniques, she unravels the complexities of antibody-Siglec and glycan-Siglec interactions, laying the foundation for purpose-fit therapeutic molecules through protein engineering and chemical biology. Simultaneously, she delves into the generation and characterization of antibodies targeting tumor associated glycans, contributing to advancements in cancer immunotherapy.
Awards & recognitions
Ikerbasque Research Associate awarded by the Basque Foundation for Science (2024). “Consolidación Investigadora” by the Spanish Ministry of Science, Innovation and Universities (2024). R3 certificate by the Spanish Ministry of Science, Innovation and Universities (2023). BBVA Leonardo Grant for scientists and creators (2023). Ikerbasque Research Fellow awarded by the Basque Foundation for Science (2019). Juan de la Cierva Incorporación Program awarded by the Spanish Ministry of Science and Innovation (2019). Banting Postdoctoral Research Fellow from the Canadian Institutes of Health Research (CIHR) (2016). AUSE PhD Award from the Spanish Association of Synchrotron Users (2017). Restracomp Award for Postdoctoral Research from The Hospital for Sick Children, Canada (2016). Jose Tormo Prize awarded by the Spanish Society of Biochemistry and Molecular Biology (SEBBM) (2014). Predoctoral Mobility Grants awarded by the Basque Regional Government for a research stay at the University of Colorado, US (2013). Research Staff Training Predoctoral Program awarded by the Basque Regional Government (2011).
Collaborations
Collaborations are integral to her research, extending across Europe, North America, and Japan. Notable partnerships include esteemed institutions like the University Nova Lisbon (F. Marcelo, P. Videira), University of Berlin (M. Schubert), Radboud University (T. Boltje), Scripps, University of Alberta (M. Macauley), the Scripps Research Institute (J. Paulson), and Tokyo Medical and Dental University (T. Tsubata). Additionally, collaborations with Basque entities such as CIC biomaGUNE, Biofisika, Biolan, and Zelula Biopharma S.L. have enriched and expanded the impact of her investigations.
Latest Publications
2023
2022
2021
2020
2019
2018
2017
It is well recognised that the clinical response of immunotherapies depends on the ability of T-cells to mount an effective effector response, persist in treated patients and avoid exhaustion and toxicities. Several approaches to immunotherapy have shown promise in clinical trials, especially the use of immune checkpoint inhibitors and, more recently, autologous adoptive T-cell therapies. However, current state-of-the-art immunotherapies are only effective in a small fraction of patients, offering a medical need to be addressed in several cancer types.
Importantly, the tumor microenvironment has specific features that impact the immune response, including decreased oxygenation, aberrant vascularization and altered nutrient availability; all these influence the success of immunotherapies.
Our research is focused on elucidating the role of the oxygen sensing machinery in T cell function, and the link of hypoxia-driven metabolism and epigenetic modifications with T cell differentiation into effector and memory T cells within the context of cancer immunotherapy. Our current aims are to exploit these findings with a multi-disciplinary strategy, to deliver several early-stage drug discovery outputs. Our main objectives are:
1. Development of novel small molecule inhibitors to modulate the hypoxic response in T cells.
2. Therapeutic target discovery in T cells, focused on hypoxia-driven epigenetic modifications.
3. Development of hypoxia-responsive approaches for adoptive T cell therapy.
Successful completion of these aims will allow us to further innovate, harness this pathway for therapeutic potential and explore potential combinatorial approaches.
-
Group Leader
Asís Palazón
Ramón y Cajal (RyC) Programme - Ikerbasque Research Associate POSTDOCTORAL RESEARCHER -
María Elena Laugieri
Juan de la Cierva Fellow -
Lorena Pérez Gutiérrez
Juan de la Cierva Fellow TECHNICIANS / DOCTORAL CANDIDATES -
Ander de Blas Martín
AECC Predoctoral Felow -
Eunate Valdaliso Díez
-
Jone Etxaniz Díaz de Durana
-
Alexandre Bosch Martínez
AECC Predoctoral Felow -
Asier Antoñana Vildosola
-
Borja Jimenez Lasheras
-
So Young Lee
-
Iker Oyenarte
-
Paloma Velasco Beltrán
-
Klaudia Sobczak
MSCA-ITN Fellow
Members
Latest Publications
SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer.
Lachiondo-Ortega, Sofia; Rejano-Gordillo, Claudia M; Simon, Jorge; Lopitz-Otsoa, Fernando; C Delgado, Teresa; Mazan-Mamczarz, Krystyna; Goikoetxea-Usandizaga, Naroa; Zapata-Pavas, L Estefania; ...
Cell reports
2024-03-26
Unraveling Molecular Recognition of Glycan Ligands by Siglec-9 via NMR Spectroscopy and Molecular Dynamics Modeling
Atxabal, U; Nycholat, C; Pröpster, JM; Fernández, A; Oyenarte, I; Lenza, MP; Franconetti, A; Soares, CO; Coelho, H; Marcelo, F; Schubert, M; Paulson, JC; Jiménez-Barbero, J; Ereño-Orbea, J;
ACS CHEMICAL BIOLOGY
2024-02-16
Targeting the Spike: Repurposing Mithramycin and Dihydroergotamine to Block SARS-CoV-2 Infection
Stagnoli, S; Macari, G; Corsi, P; Capone, B; Vidaurrazaga, A; Ereño-Orbea, J; Ardá, A; Polticelli, F; Jiménez-Barbero, J; Abrescia, NGA; Coluzza, I;
ACS OMEGA
2023-11-13
Factor-inhibiting HIF (FIH) promotes lung cancer
García-del Río, AGD; Prieto-Fernández, E; Egia-Mendikute, L; Antonana-Vildosola, A; Jimenez-Lasheras, B; Lee, SY; Barreira-Manrique, A; Zanetti, SR; de Blas, A; Velasco-Beltrán, P; Bosch, A; ...
JCI INSIGHT
2023-10-23
Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death
Sauve, F; Nampoothiri, S; Clarke, SA; Fernandois, D; Coêlho, CFF; Dewisme, J; Mills, EG; Ternier, G; Cotellessa, L; Iglesias-Garcia, C; Mueller-Fielitz, H; Lebouvier, T; Perbet, R; Florent, ...
EBIOMEDICINE
2023-10-01
The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function
Foskolou, IP; Cunha, PP; Sanchez-Lopez, E; Minogue, EA; Nicolet, BP; Guislain, A; Jorgensen, C; Kostidis, S; Zandhuis, ND; Barbieri, L; Bargiela, D; Nathanael, D; Tyrakis, PA; Palazon, A; Giera, ...
CELL REPORTS
2023-09-26
Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b
Lenza, MP; Egia-Mendikute, L; Antoñana-Vildosola, A; Soares, CO; Coelho, H; Corzana, F; Bosch, A; Manisha, P; Quintana, JI; Oyenarte, I; Unione, L; Moure, MJ; Azkargorta, M; Atxabal, U; Sobczak, ...
NATURE COMMUNICATIONS
2023-06-13
Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody
Lenza, MP; Atxabal, U; Nycholat, C; Oyenarte, I; Franconetti, A; Quintana, JI; Delgado, S; Núñez-Franco, R; Marroquin, CTG; Coelho, H; Unione, L; Jiménez-Oses, G; Marcelo, F; Schubert, M; Paulson, ...
JACS AU
2023-01-23
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes
Mercado-Gómez, M; Prieto-Fernández, E; Goikoetxea-Usandizaga, N; Vila-Vecilla, L; Azkargorta, M; Bravo, M; Serrano-Maciá, M; Egia-Mendikute, L; Rodríguez-Agudo, R; Lachiondo-Ortega, S; Lee, ...
COMMUNICATIONS BIOLOGY
2022-08-17
Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods
Stagnoli, S; Peccati, F; Connell, SR; Martinez-Castillo, A; Charro, D; Millet, O; Bruzzone, C; Palazon, A; Arda, A; Jimenez-Barbero, J; Ereno-Orbea, J; Abrescia, NGA; Jimenez-Oses, G;
FRONTIERS IN MICROBIOLOGY
2022-04-15
The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View
Unione, L; Moure, MJ; Lenza, MP; Oyenarte, I; Ereño-Orbea, J; Ardá, A; Jiménez-Barbero, J;
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2022-03-07
Enabling CAR-T cells for solid tumors: Rage against the suppressive tumor microenvironment
Antoñana-Vildosola, A; Zanetti, SR; Palazon, A; Aranda, F; Berraondo, P; Galluzzi, L;
ADOPTIVE CELL TRANSFER
2022-01-01
Molecular Recognition Insights of Sialic Acid Glycans by Distinct Receptors Unveiled by NMR and Molecular Modeling
Soares, CO; Grosso, AS; Ereno-Orbea, J; Coelho, H; Marcelo, F;
FRONTIERS IN MOLECULAR BIOSCIENCES
2021-11-15
Systematic Engineering of Optimized Autonomous Heavy-Chain Variable Domains
Nilvebrant, J; Ereño-Orbea, J; Gorelik, M; Julian, MC; Tessier, PM; Julien, JP; Sidhu, SS;
JOURNAL OF MOLECULAR BIOLOGY
2021-09-22
Structural details of monoclonal antibody m971 recognition of the membrane-proximal domain of CD22
Ereño-Orbea, J; Liu, XL; Sicard, T; Kucharska, I; Li, W; Borovsky, D; Cui, H; Feng, Y; Dimitrov, DS; Julien, JP;
JOURNAL OF BIOLOGICAL CHEMISTRY
2021-08-01
Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate
Prieto-Fernández, E; Egia-Mendikute, L; Vila-Vecilla, L; Bosch, A; Barreira-Manrique, A; Lee, SY; García-del Río, A; Antoñana-Vildosola, A; Jiménez-Lasheras, B; Moreno-Cugnon, L; Jiménez-Barbero, ...
EMERGING MICROBES & INFECTIONS
2021-01-01
Current Status on Therapeutic Molecules Targeting Siglec Receptors
Lenza, MP; Atxabal, U; Oyenarte, I; Jiménez-Barbero, J; Ereño-Orbea, J;
CELLS
2020-12-01
Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins
Lenza, MP; Oyenarte, I; Diercks, T; Quintana, JI; Gimeno, A; Coelho, H; Diniz, A; Peccati, F; Delgado, S; Bosch, A; Valle, M; Millet, O; Abrescia, NGA; Palazn, A; Marcelo, F; Jiménez-Osés, G; ...
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2020-10-22
Hypoxia Promotes Syndecan-3 Expression in the Tumor Microenvironment
Prieto-Fernandez, E; Egia-Mendikute, L; Bosch, A; del Río, AG; Jimenez-Lasheras, B; Antoñana-Vildosola, A; Lee, SY; Palazon, A;
FRONTIERS IN IMMUNOLOGY
2020-09-30
CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape
Rodriguez-Garcia, A; Palazon, A; Noguera-Ortega, E; Powell, DJ; Guedan, S;
FRONTIERS IN IMMUNOLOGY
2020-06-17
The Chemical Glycobiology Lab is actively engaged in extensive multidisciplinary studies on diverse glycan-lectin systems related to health and disease. This collaborative research involves Senior (Jimenez-Barbero, Ardá, Ereño-Orbea, Unione) and Emerging Scientists (Gimeno), along with Specialists, Technicians, Postdoctoral associates, and Doctoral candidates.
Using a combination of diverse and synergic methodologies, including chemical synthesis, protein biochemistry and molecular biology, biophysics (ITC, BLI), molecular modelling, and structural biology (X-Ray crystallography and CryoEM), with special emphasis on NMR spectroscopy, the Chemical Glycobiology lab investigates the interactions of glycans related to immune responses, from cancer to bacterial and viral infections.
Indeed, glycans, prevalent on mammalian cells and in the extracellular matrix, collectively form the glycocalyx, impacting physical properties, regulating protein function, and acting as ligands for lectins. Dysregulation of glycosyltransferases results in tumor-associated carbohydrate antigens (TACAs), unique to tumor cells. While TACAs are recognized therapeutic targets, their low immunogenicity presents a challenge for T-cell-dependent immune responses crucial in cancer therapy. TACAs play a crucial role in modulating immune responses within the tumor microenvironment through interactions with lectins. Similar interactions are observed in bacterial and viral-mediated infectious events.
From the application side, the focus is on structure-based drug and vaccine design, collaborating with research groups and pharmaceutical companies worldwide, investigating lectin-glycan and antibody-glycan molecular recognition processes. Additionally, from the basic perspective, we explore the conformational properties of glycans, specially the glycosyl oxocarbenium cations, key intermediates in synthesis and cleavage, and examine the presentation and dynamic properties of glycans designed for specific geometrical shapes.
In parallel, the laboratory continuously develops cutting-edge NMR-based techniques. Special emphasis is placed on the use of stable isotopes (13C, 19F) to push the boundaries of NMR applications. These advancements are vital for understanding the pivotal roles of glycans in their interactions with receptors, influencing biological responses associated with health or disease.
Specific areas and research lines include:
- • Interactions of glycans with galectins and C-type lectins, overseen by Dr. Ana Ardá.
- • Recognition of sialic acids by Siglecs and their role as glyco-immune checkpoints, led by Dr. June Ereño-Orbea.
- • Attachment of glycans to influenza virus proteins and other pathogens, investigating their impact on infections, directed by Dr. Luca Unione.
- • Analysis of proteoglycans and the functional landscape of glycosylation in cancer, spearheaded by Dr. Ana Gimeno.
-
Scientific Director
Jesús Jiménez-Barbero
ERC Advanced Grant - Ikerbasque Research Professor Associate Principal Investigator -
Luca Unione
ERC Starting Grant - Ikerbasque Research Associate - Juan de la Cierva Fellow -
Ana Arda
Ikerbasque Research Associate Emerging Scientist -
Ana Maria Gimeno Cardells
Ramón y Cajal (RyC) Programme - Ikerbasque Research Fellow SPECIALIST -
Ana Poveda
POSTDOCTORAL RESEARCHER -
Marta Gutierrez Lete
-
Maria Jesús Moure García
-
Pablo Valverde Sánchez
MSCA-GF Fellow -
Iris Alicia Bermejo Ruíz
MSCA-PF Fellow -
María Elena Laugieri
Juan de la Cierva Fellow TECHNICIANS / DOCTORAL CANDIDATES -
Juan Carlos Jaime Rodríguez
-
Sandra Delgado
-
Iker Oyenarte
-
Klaudia Sobczak
MSCA-ITN Fellow -
Mirane Florencio Zabaleta
-
Alberto Marina
Members
Latest Publications
SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer.
Lachiondo-Ortega, Sofia; Rejano-Gordillo, Claudia M; Simon, Jorge; Lopitz-Otsoa, Fernando; C Delgado, Teresa; Mazan-Mamczarz, Krystyna; Goikoetxea-Usandizaga, Naroa; Zapata-Pavas, L Estefania; ...
Cell reports
2024-03-26
Unraveling Molecular Recognition of Glycan Ligands by Siglec-9 via NMR Spectroscopy and Molecular Dynamics Modeling
Atxabal, U; Nycholat, C; Pröpster, JM; Fernández, A; Oyenarte, I; Lenza, MP; Franconetti, A; Soares, CO; Coelho, H; Marcelo, F; Schubert, M; Paulson, JC; Jiménez-Barbero, J; Ereño-Orbea, J;
ACS CHEMICAL BIOLOGY
2024-02-16
Targeting the Spike: Repurposing Mithramycin and Dihydroergotamine to Block SARS-CoV-2 Infection
Stagnoli, S; Macari, G; Corsi, P; Capone, B; Vidaurrazaga, A; Ereño-Orbea, J; Ardá, A; Polticelli, F; Jiménez-Barbero, J; Abrescia, NGA; Coluzza, I;
ACS OMEGA
2023-11-13
Factor-inhibiting HIF (FIH) promotes lung cancer
García-del Río, AGD; Prieto-Fernández, E; Egia-Mendikute, L; Antonana-Vildosola, A; Jimenez-Lasheras, B; Lee, SY; Barreira-Manrique, A; Zanetti, SR; de Blas, A; Velasco-Beltrán, P; Bosch, A; ...
JCI INSIGHT
2023-10-23
Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death
Sauve, F; Nampoothiri, S; Clarke, SA; Fernandois, D; Coêlho, CFF; Dewisme, J; Mills, EG; Ternier, G; Cotellessa, L; Iglesias-Garcia, C; Mueller-Fielitz, H; Lebouvier, T; Perbet, R; Florent, ...
EBIOMEDICINE
2023-10-01
The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function
Foskolou, IP; Cunha, PP; Sanchez-Lopez, E; Minogue, EA; Nicolet, BP; Guislain, A; Jorgensen, C; Kostidis, S; Zandhuis, ND; Barbieri, L; Bargiela, D; Nathanael, D; Tyrakis, PA; Palazon, A; Giera, ...
CELL REPORTS
2023-09-26
Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b
Lenza, MP; Egia-Mendikute, L; Antoñana-Vildosola, A; Soares, CO; Coelho, H; Corzana, F; Bosch, A; Manisha, P; Quintana, JI; Oyenarte, I; Unione, L; Moure, MJ; Azkargorta, M; Atxabal, U; Sobczak, ...
NATURE COMMUNICATIONS
2023-06-13
Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody
Lenza, MP; Atxabal, U; Nycholat, C; Oyenarte, I; Franconetti, A; Quintana, JI; Delgado, S; Núñez-Franco, R; Marroquin, CTG; Coelho, H; Unione, L; Jiménez-Oses, G; Marcelo, F; Schubert, M; Paulson, ...
JACS AU
2023-01-23
Metal Nodes of Metal-Organic Frameworks can Activate Molecular Hydrogen
Melillo, A; Franconetti, A; Alvaro, M; Ferrer, B; Garcia, H;
CHEMISTRY-A EUROPEAN JOURNAL
2022-11-07
Selective Exoenzymatic Labeling of Lipooligosaccharides of Neisseria gonorrhoeae with α2,6-Sialoside Analogues
de Jong, H; Moure, MJ; Hartman, JEM; Bosman, GP; Ong, JY; Bardoel, BW; Boons, GJ; Wösten, MMSM; Wennekes, T;
CHEMBIOCHEM
2022-08-23
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes
Mercado-Gómez, M; Prieto-Fernández, E; Goikoetxea-Usandizaga, N; Vila-Vecilla, L; Azkargorta, M; Bravo, M; Serrano-Maciá, M; Egia-Mendikute, L; Rodríguez-Agudo, R; Lachiondo-Ortega, S; Lee, ...
COMMUNICATIONS BIOLOGY
2022-08-17
Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods
Stagnoli, S; Peccati, F; Connell, SR; Martinez-Castillo, A; Charro, D; Millet, O; Bruzzone, C; Palazon, A; Arda, A; Jimenez-Barbero, J; Ereno-Orbea, J; Abrescia, NGA; Jimenez-Oses, G;
FRONTIERS IN MICROBIOLOGY
2022-04-15
The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View
Unione, L; Moure, MJ; Lenza, MP; Oyenarte, I; Ereño-Orbea, J; Ardá, A; Jiménez-Barbero, J;
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2022-03-07
Enabling CAR-T cells for solid tumors: Rage against the suppressive tumor microenvironment
Antoñana-Vildosola, A; Zanetti, SR; Palazon, A; Aranda, F; Berraondo, P; Galluzzi, L;
ADOPTIVE CELL TRANSFER
2022-01-01
Microwave-assisted palladium catalysed C-H acylation with aldehydes: synthesis and diversification of 3-acylthiophenes
Santiago, C; Jiménez-Aberasturi, X; Leicea, E; Lete, MG; Sotomayor, N; Lete, E;
ORGANIC & BIOMOLECULAR CHEMISTRY
2021-12-22
Unveiling the role of pyrylium frameworks on π-stacking interactions: a combined ab initio and experimental study
Núñez-Franco, R; Jiménez-Osés, G; Jiménez-Barbero, J; Cabrera-Escribano, F; Franconetti, A;
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
2021-09-24
Molecular Recognition Insights of Sialic Acid Glycans by Distinct Receptors Unveiled by NMR and Molecular Modeling
Soares, CO; Grosso, AS; Ereno-Orbea, J; Coelho, H; Marcelo, F;
FRONTIERS IN MOLECULAR BIOSCIENCES
2021-11-15
Systematic Engineering of Optimized Autonomous Heavy-Chain Variable Domains
Nilvebrant, J; Ereño-Orbea, J; Gorelik, M; Julian, MC; Tessier, PM; Julien, JP; Sidhu, SS;
JOURNAL OF MOLECULAR BIOLOGY
2021-09-22
Structural details of monoclonal antibody m971 recognition of the membrane-proximal domain of CD22
Ereño-Orbea, J; Liu, XL; Sicard, T; Kucharska, I; Li, W; Borovsky, D; Cui, H; Feng, Y; Dimitrov, DS; Julien, JP;
JOURNAL OF BIOLOGICAL CHEMISTRY
2021-08-01
Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate
Prieto-Fernández, E; Egia-Mendikute, L; Vila-Vecilla, L; Bosch, A; Barreira-Manrique, A; Lee, SY; García-del Río, A; Antoñana-Vildosola, A; Jiménez-Lasheras, B; Moreno-Cugnon, L; Jiménez-Barbero, ...
EMERGING MICROBES & INFECTIONS
2021-01-01