Seminar

Animal models of human diseases: the contribution of metabolomics

Maria Chiara Mimmi, PhD

A multidisciplinary research platform is investigating on congenital pulmonary malformations. Ovine models were created to develop innovative therapies by prenatal surgery. The metabolomics/lipidomics study, conducted on the animal biofluids, will be illustrated. New transgenic C. elegans strains, expressing wild type human β(2)-microglobulin and its highly amyloidogenic variants, have been established and characterized. The metabolic profile of transgenic C. elegans correlates with the exogenous protein toxicity to the multicellular model. CV of Maria Chiara Mimmi MC Mimmi completed her Ph.D in Chemistry in 2003 at the University of Milan, Italy. She dedicated her postdoctoral research to the biophysical characterization of amiloidogenic proteins. Since 2010 she oriented her research activity towards metabolomics. MC Mimmi is assistant professor at University of Udine and she is currently leading two projects, awarded financial support from the Italian Ministry of University and Research (MIUR) and from the Surgery Unit of San Matteo Foundation (Pavia, Italy) respectively.