Special Lecture

Tumor suppressor genes in cancer and beyond

Manuel Serrano, PhD

My seminar will have three parts, each of them with unpublished data. First, I will review the current knowledge about cellular senescence and its role in tumor suppression. I will present our most recent data on the interplay between inflammation and senescence, and on the role of senescence during embryonic development. In the second part, I will present our most recent data on a new preclinical approach against lung cancer targeting the Notch pathway. This will include state-of-the-art in vivo imaging in mice. Finally, I will present our new data on the role of cell cycle regulators during the process of reprogramming of differentiated cells into induced pluripotent stem cells (iPSCs).