Seminar

Understanding and controlling protein-protein interactions

Grzegorz Popowicz, PhD

Protein - protein interactions (PPI) were considered impossible to target with a drug molecule. However, recent development of both computational and experimental techniques prove that targetting PPIs is possible. We have developen a PPI oriented drug design program with a focus on Mdm2 and Mdmx oncoproteins. Our research required development of novel NMR and biophysical experiments and computational methods. This approach allowed for discovery of several scaffolds active bot in in vitro and in vivo experiments. We propose, using similar strategy for targetting novel, recently discovered PPIs.