2011/01/19

Different DNA binding modes for p53 tumor suppressor

Tumor suppressor p53 is a transcription factor that plays a central role in cell cycle control, and mutations in the protein are related to nearly 50 % of human tumours. Collaboration between groups of Alan Fersht (MRC) and Mikel Valle (CICbioGUNE) has provided new insight into the structure of p53 tetramers while bound to DNA.