2011/01/20

Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice

 

Prohibitin 1 is a highly conserved, ubiquitously expressed protein that participates in diverse processes including mitochondrial chaperone interactions, growth and apoptosis. Researchers from the Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, in collaboration with the Metabolomics Unit of CIC bioGUNE, have generated a liver-specific Phb1 KO mice. The results of their study demonstrate a vital role for PHB1 in normal liver physiology and supports its role as a tumor suppressor in liver.


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2011/01/19

Different DNA binding modes for p53 tumor suppressor

 Tumor suppressor p53 is a transcription factor that plays a central role in cell cycle control, and mutations in the protein...

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2011/01/20

Prohibiting hepatocytes to lose control

  Hepatocellular carcinoma (HCC) is the most frequent primary malignant tumor type in the liver. Whereas the etiology frequently...

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