2015/07/15

Monitoring Glycan-Protein Interactions by NMR Spectroscopic Analysis: A Simple Chemical Tag That Mimics Natural CH-π Interactions

Detection of molecular recognition processes requires robust, specific and easily implementable sensing methods, especially for screening applications related to the drug discovery process. Within a collaborative project between the research groups of Niels Reichardt at CIC biomaGUNE and Jesús Jiménez-Barbero at CIC bioGUNE, complemented by the efforts of the CIC bioGUNE NMR platform manager (Tammo Diercks) and other scientists at CSIC, a novel chemical tag has been devised to monitor glycan-receptor binding events. The proposed difluoroacetamide tag contains 1H and 19F atoms that allow applying both 1H- and 19F-observed NMR methods for easy sensing of glycan-mediated interactions.

Detailed information is available from http://dx.doi.org/10.1002/chem.201501248