Marco Piva
mpiva
Marco Piva
EMERGING SCIENTIST
Ikerbasque Research Fellow Ramón y Cajal (RyC) Programme
Ikerbasque Research Fellow Ramón y Cajal (RyC) Programme
Cancer Cell Signaling And Metabolism Lab
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

Marco Piva obtained his BSc in Biotecnology from the University of Bologna and continued his scientific pursuits by completing his PhD in Biochemistry and Molecular Biology from the University of the Basque Country (UPV/EHU) and CIC bioGUNE, Spain.

In 2014, Dr. Piva joined the laboratory Prof. Roger S. Lo at the University of California Los Angeles (UCLA) (USA). In his postdoctoral research he focused on the study of the mechanism of drug resistance in melanoma.

In 2021, Dr. Piva became a Ramón y Cajal and Ikerbasque Research Fellow (2019) in the Cancer Cell Signaling and Metabolism Lab at CIC bioGUNE and he currently holds the position of Emerging Scientist.
Dr. Piva’s research focuses on how the immune compartment influences tumor progression, therapy response, and resistance. His work explores the interactions between cancer cells and the tumor microenvironment (TME), with a particular emphasis on neutrophils and macrophages, which can both support and suppress metastatic disease.

His lab investigates the immune-driven mechanisms that promote metastasis and therapy resistance, aiming to reprogram tumor microenvironment to improve treatment outcomes. By targeting immunosuppressive processes and exploring new therapeutic strategies, their research seeks to enhance the efficacy of immunotherapy and address the challenges of metastatic cancer.

Research line 1: Targeting immune-driven inflammation in metastatic cancers
Chronic inflammation within the TME drives tumor growth, immune evasion, and resistance to therapy. The group aims to identify and target the inflammatory processes mediated by immune cells, such as the release of pro-tumoral factors and the formation of extracellular structures that facilitate metastatic dissemination. By developing and testing therapeutic agents in preclinical models, they seek to design strategies that block harmful immune functions while preserving beneficial immune responses.

Research line 2: Understanding immune cell contributions to therapy resistance.
Key immune cell populations, such as macrophages and neutrophils, play significant roles in shaping the TME and promoting tumor progression in metastatic cancers. These cells often support tumor growth, suppress effective anti-tumor immunity, and contribute to resistance against current therapies. By investigating their functional states and interactions with other TME components, the group aims to uncover mechanisms of resistance and develop strategies to reprogram these immune cells for therapeutic benefit.

Research line 3: Translational profiling of the tumor immune microenvironment
To bridge the gap between preclinical findings and clinical applications, the lab utilizes advanced profiling technologies to analyze the TME in metastatic cancers. These approaches enable them to identify key pathways and regulatory networks that mediate tumor-immune interactions and prioritize actionable targets for therapy. By integrating findings from both preclinical models and patient samples, they aim to ensure that their research is both relevant and translatable.

Research line 4: Designing effective combination therapies
Combining standard-of-care treatments with immune-targeting strategies offers great promise for improving outcomes in metastatic cancers. Their research explores novel combinations of therapies that simultaneously target cancer cells and modulate the immune microenvironment, with the goal of achieving more durable responses and reducing resistance. Preclinical validation in advanced models will inform the development of these approaches for clinical use.

By focusing on the immune system’s role in metastatic progression, the lab seeks to uncover novel therapeutic opportunities that enhance treatment efficacy and address unmet clinical needs. Through the development of innovative therapies and the integration of translational insights, the group aims to contribute to improving survival rates and quality of life for patients affected by metastatic cancers.

Dr. Piva’s team includes PhD candidate Victoria Cid Cetelles and Juan de la Cierva postdoctoral researcher Jaione Auzmendi Iriarte.

Awards & recognitions
Ramón y Cajal Fellow and Ikerbasque Research Fellow (2019).

Collaborations
Joaquín Mateo (VHIO, Barcelona), María Casanova (CNIO, Madrid), Edurne Rujas (Fundación Biofisika/Euskal Herriko Unibertsitatea, Bilbao/Vitoria), Natalia Elguezabal (Neiker, Derio-Zamudio).

Latest Publications

2020

2018

2017

2016

2014

The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:

  • Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
  • Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
  • Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
Latest Publications

A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease

Conduit, SE; Pearce, W; Bhamra, A; Bilanges, B; Bozal-Basterra, L; Foukas, LC; Cobbaut, M; Castillo, SD; Danesh, MA; Adil, M; Carracedo, A; Graupera, M; McDonald, NQ; Parker, PJ; Cutillas, PR; ...

NATURE COMMUNICATIONS

2024-08-21

MetSCORE: a molecular metric to evaluate the risk of metabolic syndrome based on serum NMR metabolomics

Gil-Redondo, R; Conde, R; Bruzzone, C; Seco, ML; Bizkarguenaga, M; González-Valle, B; de Diego, A; Lain, A; Habisch, H; Haudum, C; Verheyen, N; Obermayer-Pietsch, B; Margarita, S; Pelusi, S; ...

CARDIOVASCULAR DIABETOLOGY

2024-07-24

Metastatic hormone-naïve prostate cancer: a distinct biological entity

Corres-Mendizabal, J; Zacchi, F; Martín-Martín, N; Mateo, J; Carracedo, A;

TRENDS IN CANCER

2024-07-23

The PP2A regulator IER5L supports prostate cancer progression

Crespo, JR; Martín-Martín, N; Garcia-Longarte, S; Corres-Mendizabal, J; Carlevaris, O; Astobiza, I; Zabala-Letona, A; Guiu, M; Azkargorta, M; Gonzalez-Lopez, M; Macías-Cámara, N; Doan, P; Elortza, ...

CELL DEATH & DISEASE

2024-07-18

Metabolic adaptations in prostate cancer

Pujana-Vaquerizo, M; Bozal-Basterra, L; Carracedo, A;

BRITISH JOURNAL OF CANCER

2024-07-05

SERS analysis of cancer cell- secreted purines reveals a unique paracrine crosstalk in MTAP- deficient tumors

Valera, PS; Plou, J; Garcia, I; Astobiza, I; Viera, C; Aransay, AM; Martin, JE; Sasselli, IR; Carracedo, A; Liz-Marzan, LM;

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2023-12-26

STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

Pencik, J; Philippe, C; Schlederer, M; Atas, E; Pecoraro, M; Grund-Gröchke, S; Li, W; Tracz, A; Heidegger, I; Lagger, S; Trachtová, K; Oberhuber, M; Heitzer, E; Aksoy, O; Neubauer, HA; Wingelhofer, ...

MOLECULAR CANCER

2023-08-12

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

García-Vilchez, R; Anazco-Guenkova, AM; Dietmann, S; López, J; Morón-Calvente, V; DAmbrosi, S; Nombela, P; Zamacola, K; Mendizabal, I; García-Longarte, S; Zabala-Letona, A; Astobiza, I; Fernández, ...

MOLECULAR CANCER

2023-07-29

Metabolism in the tumor cell and beyond

Carracedo, A;

MOLECULAR ONCOLOGY

2023-06-06

Machine Learning-Assisted High-Throughput SERS Classification of Cell Secretomes

Plou, J; Valera, PS; García, I; Vila-Liarte, D; Renero-Lecuna, C; Ruiz-Cabello, J; Carracedo, A; Liz-Marzán, LM;

SMALL

2023-04-12

Identifying prognostic parameters related to surgical technique in patients treated by robotic radical prostatectomy

Iriarte, AL; Viscasillas, IL; Gonzalez, SR; Martín, AS; Aparicio, DG; Olano, AU; Pérez, AC; Urzaiz, MU;

ACTAS UROLOGICAS ESPANOLAS

2023-01-01

Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer

Santasusagna, S; Zhu, S; Jawalagatti, V; Carceles-Cordon, M; Ertel, A; Garcia-Longarte, S; Song, WM; Fujiwara, N; Li, P; Mendizabal, I; Petrylak, DP; Kelly, WK; Reddy, EP; Wang, L; Schiewer, ...

CANCER DISCOVERY

2023-01-01

CiberAMP: An R Package to Identify Differential mRNA Expression Linked to Somatic Copy Number Variations in Cancer Datasets

Caloto, R; Lorenzo-Martín, LF; Quesada, V; Carracedo, A; Bustelo, XR;

BIOLOGY-BASEL

2022-10-01

RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress

Feu, S; Unzueta, F; Ercilla, A; Pérez-Venteo, A; Jaumot, M; Agell, N;

PLOS ONE

2022-08-15

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Davidson, SM; Schmidt, DR; Heyman, JE; Brien, JPO; Liu, AC; Israelsen, WJ; Dayton, TL; Sehgal, R; Bronson, RT; Freinkman, E; Mak, HH; Fanelli, GN; Malstrom, S; Bellinger, G; Carracedo, A; Pandolfi, ...

CANCER RESEARCH

2022-07-01

Epigenetic Mechanisms Influencing Therapeutic Response in Breast Cancer

Arruabarrena-Aristorena, A; Toska, E;

FRONTIERS IN ONCOLOGY

2022-06-14

Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen

Rodríguez-Agudo, R; Goikoetxea-Usandizaga, N; Serrano-Maciá, M; Fernández-Tussy, P; Fernández-Ramos, D; Lachiondo-Ortega, S; González-Recio, I; Gil-Pitarch, C; Mercado-Gómez, M; Morán, L; Bizkarguenaga, ...

ANTIOXIDANTS

2022-05-01

High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML

Aldaz, P; Martín-Martín, N; Saenz-Antoñanzas, A; Carrasco-Garcia, E; Alvarez-Satta, M; Elúa-Pinin, A; Pollard, SM; Lawrie, CH; Moreno-Valladares, M; Samprón, N; Hench, J; Lovell-Badge, R; Carracedo, ...

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2022-05-01

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

Araujo, AM; Abaurrea, A; Azcoaga, P; López-Velazco, J; Manzano, S; Rodriguez, J; Rezola, R; Egia-Mendikute, L; Valdés-Mora, F; Flores, JM; Jenkins, L; Pulido, L; Osorio-Querejeta, I; Fernández-Nogueira, ...

JOURNAL OF CLINICAL INVESTIGATION

2022-04-01

Angiocrine polyamine production regulates adiposity

Monelli, E; Villacampa, P; Zabala-Letona, A; Martinez-Romero, A; Llena, J; Beiroa, D; Gouveia, L; Chivite, I; Zagmutt, S; Gama-Perez, P; Osorio-Conles, O; Muixi, L; Martinez-Gonzalez, A; Castillo, ...

NATURE METABOLISM

2022-03-14