Maria Camila Salazar Palacio
Maria Camila Salazar Palacio
LABORATORY TECHNICIAN
Cancer Cell Signaling And Metabolism Lab & Metabolomics Platform
Email: msalazar@cicbiogune.es
Phone: 4229 / 944 061 317
Address: Bizkaia Science and Technology Park, building 801A, Derio (Bizkaia)

The research in the Carracedo lab is aimed at deconstructing the essential requirements of cancer cells with special emphasis on the translation of the acquired knowledge from bench to bedside. In order to define the genuine features of cancer cells, we focus on the signalling and metabolic alterations in prostate and breast cancer. Through the use of a hierarchical approach with increasing complexity, we work on cell lines and primary cultures (using cell and molecular biology technologies), mouse models of prostate cancer that are faithful to the human disease and the analysis of human specimens through the development of prospective and retrospective studies. Our work stems from the hypothesis that cancer is driven by signalling and metabolic alterations that, once identified, can be targeted for therapy. The center and our collaborator institutions offer state-of-the-art technologies (from OMICS to in vivo imaging), which allow us to build and answer our hypotheses with high level of confidence.
To address our scientific questions in cancer, the Carracedo lab has developed a series of research lines:

  • Bioinformatics-based discovery. The lab takes full advantage on publicly available human prostate and breast cancer datasets in order to identify candidate genes to contribute to cancer pathogenesis, progression and response to therapy. Best hits are then validated employing genetic mouse models, xenograft surrogate assays and the latest advances in cellular and molecular biology combined with OMICs technologies.
  • Genetic mouse models as a source for the identification of novel cancer players. Genetically engineered mouse models (GEMMs) can faithfully recapitulate many aspects of human cancer. Dr. Carracedo envisions the molecular analysis of GEMMs with high throughput technologies as a mean to identify novel cancer-related genes. These hits are then validated through the analysis of human cancer specimens and cellular and molecular biology approaches.
  • Multi-OMICs analysis for non-invasive biomarker identification. Biofluids are the perfect source for cancer biomarkers that can inform about the presence or features of cancer. The lab has undertaken a biomarker discovery approach by applying the latest OMICs technologies to biofluid specimens from well-annotated prostate cancer patients, in order to define better molecules that inform about this disease.
Latest Publications

A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease

Conduit, SE; Pearce, W; Bhamra, A; Bilanges, B; Bozal-Basterra, L; Foukas, LC; Cobbaut, M; Castillo, SD; Danesh, MA; Adil, M; Carracedo, A; Graupera, M; McDonald, NQ; Parker, PJ; Cutillas, PR; ...

NATURE COMMUNICATIONS

2024-08-21

MetSCORE: a molecular metric to evaluate the risk of metabolic syndrome based on serum NMR metabolomics

Gil-Redondo, R; Conde, R; Bruzzone, C; Seco, ML; Bizkarguenaga, M; González-Valle, B; de Diego, A; Lain, A; Habisch, H; Haudum, C; Verheyen, N; Obermayer-Pietsch, B; Margarita, S; Pelusi, S; ...

CARDIOVASCULAR DIABETOLOGY

2024-07-24

Metastatic hormone-naïve prostate cancer: a distinct biological entity

Corres-Mendizabal, J; Zacchi, F; Martín-Martín, N; Mateo, J; Carracedo, A;

TRENDS IN CANCER

2024-07-23

The PP2A regulator IER5L supports prostate cancer progression

Crespo, JR; Martín-Martín, N; Garcia-Longarte, S; Corres-Mendizabal, J; Carlevaris, O; Astobiza, I; Zabala-Letona, A; Guiu, M; Azkargorta, M; Gonzalez-Lopez, M; Macías-Cámara, N; Doan, P; Elortza, ...

CELL DEATH & DISEASE

2024-07-18

Metabolic adaptations in prostate cancer

Pujana-Vaquerizo, M; Bozal-Basterra, L; Carracedo, A;

BRITISH JOURNAL OF CANCER

2024-07-05

SERS analysis of cancer cell- secreted purines reveals a unique paracrine crosstalk in MTAP- deficient tumors

Valera, PS; Plou, J; Garcia, I; Astobiza, I; Viera, C; Aransay, AM; Martin, JE; Sasselli, IR; Carracedo, A; Liz-Marzan, LM;

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2023-12-26

STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

Pencik, J; Philippe, C; Schlederer, M; Atas, E; Pecoraro, M; Grund-Gröchke, S; Li, W; Tracz, A; Heidegger, I; Lagger, S; Trachtová, K; Oberhuber, M; Heitzer, E; Aksoy, O; Neubauer, HA; Wingelhofer, ...

MOLECULAR CANCER

2023-08-12

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

García-Vilchez, R; Anazco-Guenkova, AM; Dietmann, S; López, J; Morón-Calvente, V; DAmbrosi, S; Nombela, P; Zamacola, K; Mendizabal, I; García-Longarte, S; Zabala-Letona, A; Astobiza, I; Fernández, ...

MOLECULAR CANCER

2023-07-29

Metabolism in the tumor cell and beyond

Carracedo, A;

MOLECULAR ONCOLOGY

2023-06-06

Machine Learning-Assisted High-Throughput SERS Classification of Cell Secretomes

Plou, J; Valera, PS; García, I; Vila-Liarte, D; Renero-Lecuna, C; Ruiz-Cabello, J; Carracedo, A; Liz-Marzán, LM;

SMALL

2023-04-12

Identifying prognostic parameters related to surgical technique in patients treated by robotic radical prostatectomy

Iriarte, AL; Viscasillas, IL; Gonzalez, SR; Martín, AS; Aparicio, DG; Olano, AU; Pérez, AC; Urzaiz, MU;

ACTAS UROLOGICAS ESPANOLAS

2023-01-01

Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer

Santasusagna, S; Zhu, S; Jawalagatti, V; Carceles-Cordon, M; Ertel, A; Garcia-Longarte, S; Song, WM; Fujiwara, N; Li, P; Mendizabal, I; Petrylak, DP; Kelly, WK; Reddy, EP; Wang, L; Schiewer, ...

CANCER DISCOVERY

2023-01-01

CiberAMP: An R Package to Identify Differential mRNA Expression Linked to Somatic Copy Number Variations in Cancer Datasets

Caloto, R; Lorenzo-Martín, LF; Quesada, V; Carracedo, A; Bustelo, XR;

BIOLOGY-BASEL

2022-10-01

RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress

Feu, S; Unzueta, F; Ercilla, A; Pérez-Venteo, A; Jaumot, M; Agell, N;

PLOS ONE

2022-08-15

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Davidson, SM; Schmidt, DR; Heyman, JE; Brien, JPO; Liu, AC; Israelsen, WJ; Dayton, TL; Sehgal, R; Bronson, RT; Freinkman, E; Mak, HH; Fanelli, GN; Malstrom, S; Bellinger, G; Carracedo, A; Pandolfi, ...

CANCER RESEARCH

2022-07-01

Epigenetic Mechanisms Influencing Therapeutic Response in Breast Cancer

Arruabarrena-Aristorena, A; Toska, E;

FRONTIERS IN ONCOLOGY

2022-06-14

Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen

Rodríguez-Agudo, R; Goikoetxea-Usandizaga, N; Serrano-Maciá, M; Fernández-Tussy, P; Fernández-Ramos, D; Lachiondo-Ortega, S; González-Recio, I; Gil-Pitarch, C; Mercado-Gómez, M; Morán, L; Bizkarguenaga, ...

ANTIOXIDANTS

2022-05-01

High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML

Aldaz, P; Martín-Martín, N; Saenz-Antoñanzas, A; Carrasco-Garcia, E; Alvarez-Satta, M; Elúa-Pinin, A; Pollard, SM; Lawrie, CH; Moreno-Valladares, M; Samprón, N; Hench, J; Lovell-Badge, R; Carracedo, ...

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2022-05-01

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

Araujo, AM; Abaurrea, A; Azcoaga, P; López-Velazco, J; Manzano, S; Rodriguez, J; Rezola, R; Egia-Mendikute, L; Valdés-Mora, F; Flores, JM; Jenkins, L; Pulido, L; Osorio-Querejeta, I; Fernández-Nogueira, ...

JOURNAL OF CLINICAL INVESTIGATION

2022-04-01

Angiocrine polyamine production regulates adiposity

Monelli, E; Villacampa, P; Zabala-Letona, A; Martinez-Romero, A; Llena, J; Beiroa, D; Gouveia, L; Chivite, I; Zagmutt, S; Gama-Perez, P; Osorio-Conles, O; Muixi, L; Martinez-Gonzalez, A; Castillo, ...

NATURE METABOLISM

2022-03-14

Latest Publications

Embryo-Induced Changes in the Protein Profile of Bovine Oviductal Extracellular Vesicles

Mazzarella, R; Sánchez, J; Fernandez-Fuertes, B; Egido, SG; McDonald, M; Alvarez-Barrientos, A; González, E; Falcón-Pérez, JM; Azkargorta, M; Elortza, F; González, ME; Lonergan, P; Rizos, D; ...

MOLECULAR & CELLULAR PROTEOMICS

2025-04-01

Intra and inter-organ communication through extracellular vesicles in obesity: functional role of obesesomes and steatosomes

Lago-Baameiro, N; Camino, T; Vazquez-Durán, A; Sueiro, A; Couto, I; Santos, F; Baltar, J; Falcón-Pérez, JM; Pardo, M;

JOURNAL OF TRANSLATIONAL MEDICINE

2025-02-20

Metabolic Profiling of Brain Tissue and Brain-Derived Extracellular Vesicles in Alzheimer's Disease

Hernandez, P; Rackles, E; Alboniga, OE; Martínez-Lage, P; Camacho, EN; Onaindia, A; Fernandez, M; Talamillo, A; Falcon-Perez, JM;

JOURNAL OF EXTRACELLULAR VESICLES

2025-02-01

Reproducibility of extracellular vesicle research

Crescitelli, R; Falcon-Perez, J; Hendrix, A; Lenassi, M; Minh, LN; Ochiya, T; Hooten, NN; Sandau, U; Théry, C; Nieuwland, R;

JOURNAL OF EXTRACELLULAR VESICLES

2025-01-01

Beyond basic characterization and omics: Immunomodulatory roles of platelet-derived extracellular vesicles unveiled by functional testing

Palviainen, M; Puutio, J; Ostergaard, RH; Eble, JA; Maaninka, K; Butt, U; Ndika, J; Kari, OK; Kamali-Moghaddam, M; Kjaer-Sorensen, K; Oxvig, C; Aransay, AM; Falcon-Perez, JM; Federico, A; Greco, ...

JOURNAL OF EXTRACELLULAR VESICLES

2024-10-01

Systemic messenger RNA replacement therapy is effective in a novel clinically relevant model of acute intermittent porphyria developed in non-human primates

Córdoba, KM; Jericó, D; Jiang, L; Collantes, M; Alegre, M; García-Ruiz, L; Manzanilla, O; Sampedro, A; Herranz, JM; Insausti, I; de la Cuesta, AM; Urigo, F; Alcaide, P; Morán, M; Martín, MA; ...

GUT

2024-10-01

Extracellular vesicles in tumor-adipose tissue crosstalk: key drivers and therapeutic targets in cancer cachexia

Ramos, CC; Pires, J; Gonzalez, E; Garcia-Vallicrosa, C; Reis, CA; Falcon-Perez, JM; Freitas, D;

EXTRACELLULAR VESICLES AND CIRCULATING NUCLEIC ACIDS

2024-09-01

Increased levels of circulating cell-free double-stranded nucleic acids in the plasma of glioblastoma patients.

Rackles, Elisabeth; Zaccheroni, Elena; Lopez, Patricia Hernandez; Faletti, Stefania; Bene, Massimiliano Del; DiMeco, Francesco; Pelicci, Giuliana; Falcon-Perez, Juan M;

Journal of extracellular biology

2024-08-01

Cryogenic electron microscopy reveals morphologically distinct subtypes of extracellular vesicles among porcine ejaculate fractions

Parra, A; Barranco, I; Martínez-Díaz, P; González, E; Albóniga, OE; Cabrera, D; Falcón-Pérez, JM; Roca, J;

SCIENTIFIC REPORTS

2024-07-13

Three-Dimensional Hepatocyte Spheroids: Model for Assessing Chemotherapy in Hepatocellular Carcinoma

Royo, F; Garcia-Vallicrosa, C; Azparren-Angulo, M; Bordanaba-Florit, G; Lopez-Sarrio, S; Falcon-Perez, JM;

BIOMEDICINES

2024-05-28

Integration of proteomic and metabolomic analysis reveal distinct metabolic alterations of prostate cancer-associated fibroblasts compared to normal fibroblasts from patient's stroma samples

Bordanaba-Florit, G; Royo, F; Albóniga, OE; Clayton, A; Falcón-Pérez, JM; Webber, J;

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

2024-05-10

Characterization of preovulatory follicular fluid secretome and its effects on equine oocytes during in vitro maturation

Luis-Calero, M; Marinaro, F; Fernández-Hernández, P; Ortiz-Rodríguez, JM; Casado, JG; Pericuesta, E; Gutiérrez-Adán, A; González, E; Azkargorta, M; Conde, R; Bizkarguenaga, M; Embade, N; Elortza, ...

RESEARCH IN VETERINARY SCIENCE

2024-03-11

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Welsh, JA; Goberdhan, DCI; ODriscoll, L; Buzas, EI; Blenkiron, C; Bussolati, B; Cai, HJ; Di Vizio, D; Driedonks, TAP; Erdbrügger, U; Falcon-Perez, JM; Fu, QL; Hill, AF; Lenassi, M; Lim, SK; ...

JOURNAL OF EXTRACELLULAR VESICLES

2024-02-01

Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet

Lucena, MI; Villanueva-Paz, M; Alvarez-Alvarez, I; Aithal, GP; Björnsson, ES; Cakan-Akdogan, G; Cubero, FJ; Esteves, F; Falcon-Perez, JM; Fromenty, B; Garcia-Ruiz, C; Grove, JI; Konu, O; Kranendonk, ...

PHARMACOLOGICAL RESEARCH

2024-02-01

Lipidomics and biodistribution of extracellular vesicles-secreted by hepatocytes from Zucker lean and fatty rats.

Azparren-Angulo, Maria; Mleczko, Justyna; Alboniga, Oihane E; Kruglik, Sergei; Guigner, Jean-Michel; Gonzalez, Esperanza; Garcia-Vallicrosa, Clara; Llop, Jordi; Simo, Cristina; Alonso, Cristina; ...

Journal of extracellular biology

2024-02-01

Characterization of Extracellular Vesicles from Human Saliva: Effects of Age and Isolation Techniques

Reseco, L; Molina-Crespo, A; Atienza, M; Gonzalez, E; Falcon-Perez, JM; Cantero, JL; Neri, C;

CELLS

2024-01-01

Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies

Sandau, US; Magana, SM; Costa, J; Nolan, JP; Ikezu, T; Vella, LJ; Jackson, HK; Moreira, LR; Palacio, PL; Hill, AF; Quinn, JF; Van Keuren-Jensen, KR; Mcfarland, TJ; Palade, J; Sribnick, EA; Su, ...

Journal of Extracellular Vesicles

2024-01-01

Small extracellular vesicle-based human melanocyte and melanoma signature

Agüera-Lorente, A; Alonso-Pardavila, A; Larrinaga, M; Boyano, MD; González, E; Falcón-Pérez, JM; Asumendi, A; Apraiz, A;

PIGMENT CELL & MELANOMA RESEARCH

2023-12-29

MIBlood-EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research

Lucien, F; Gustafson, D; Lenassi, M; Li, B; Teske, JJ; Boilard, E; von Hohenberg, KC; Falcon-Perez, JM; Gualerzi, A; Reale, A; Jones, JC; Laesser, C; Lawson, C; Nazarenko, I; ODriscoll, L; Pink, ...

JOURNAL OF EXTRACELLULAR VESICLES

2023-12-01

The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer

Garcia-Vallicrosa, C; Falcon-Perez, JM; Royo, F;

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2023-11-01