Activity Report 2020
Activity Report 2020
Scientific Programmes
Scientific Programmes
Research lines
Cancer
Infectious diseases
Rare diseases
The cutting-edge scientific activity of CIC bioGUNE researchers explores the interface between Chemistry and Biomedicine, with emphasis on Structural, Molecular and Cell Biology. An integrative Bioinformatics Program extrapolates relevant conclusions from basic science.
- Personalized medicine
- Prostate Cancer
- Breast Cancer
- Colorectal Cancer
- Liver Diseases
- Rare Diseases
- Biomarkers for Diagnosis
- Biomarkers for Prognosis
- Drug Design and Discovery
Molecular Recognition and Host-Pathogen
- Rare Diseases
- Homeostasis
- Viral Infections
- Bacterial Infections
- Prion Disease
- Tick-Borne Disease
- Immune Response
- Drug Design and Discovery
Platforms
- NMR Spectroscopy
- Macromolecular Crystallography
- Electron Microscopy
- Genome Analysis
- Proteomics
- Metabolomics
- Animal Facility
Generation of
knowledge
Technology
transfer
Commercialization of
results
Scientific Programmes
Metabolism & Cell Signaling in Disease
Brain
Breast
Colon
Liver
Prostate
- Target discovery and evaluation of their therapeutic potential
- Cancer and more: Identification of biomarkers with potential diagnostic value
- Novel therapies against rare diseases
- The molecular basis of fibrosis
- Nonalcoholic steatohepatitis
The Research Programmes
Molecular Recognition & Host-Pathogen Interactions
Parasites
Vaccines
Antibiotics
Membrane remodelling
Animal and plant viruses
- Bacterial and Viral Infections: Vaccines for human and animal health
- Mechanisms of membrane remodelling during microbial invasion and propagation
- Plant vaccines and transgenics
- Antibiotics research and molecular characterization
The Research Programmes
Technology Platforms
Genome Analysis Platform
Proteomics Platform
Metabolomics Platform
Animal Facility
Antibodies Production
Drug Repositioning & Discovery
Nuclear Magnetic Resonance
Macromolecular Crystallography
Electron Microscopy Platform
Collaboration Models
Services
R&D Collaborations
Consulting
About Us
Mission:
Conducting research of excellence in the field of the life sciences, covering the entire value of R&D&i, including technology transfer and commercial exploitation of the generated scientific results.
Strategic Challenges:
- Research of excellence
- Technology Transfer
- Collaboration with RVCTI agents
- International recognition
- Training and promotion of research talent
- Attraction and retention of talent
- Communication and Outreach
- Excellence in Management
Strategy:
Commitment to specialization and excellence
Competitiveness:
- Leading infrastructures
- Human Resources
- Technical and administrative support
- Competitive salaries
- Goal-Fulfillment Incentives
Staff
Staff 2020.12.31: 0
FTE (2020): 0
Permanent Staff (FTE): 0 (43%)
Gender distribution
-
0% Female
121 -
0% Male
90 -
LISMI - Law of Social Integration of the Handicapped
4
211 Total CIC bioGUNE Personnel
-
0% Research
177 -
0% Administration and Services
34
Researchers Distribution by Professional Category
| nº | % |  |
 |
||
| Researchers | 136 | 76.8 | 67 | 69 | |
| • Principal investigators/Platform Managers | 28 | 15.8 | 7 | 21 | |
| • Postdoctoral Researchers/Research Assistant/Specialist | 47 | 26.6 | 26 | 21 | |
| • PhD Students | 61 | 34.5 | 34 | 27 | |
| Technicians | 41 | 23.2 | 31 | 10 |
Research Distribution by Geographic Origin
Research Distribution by Geographic Origin
-
0% Spain
174 researchers -
0% Rest of Europe
19 researchers -
0% America
14 researchers -
0% Asia
4 researchers
Funding
Total 2020 R&D Budget: 0 k€
Running R&D Projects: 0
New R&D Projects: 0
-
0 % Basque Government Departments
8.436 K€ -
0 % MINECO & MEDC (Spanish Government)
3.554 K€ -
0 % R&D Contracts, Research Services & Others
6.014 K€ -
0 % EU & International Projects
1750 K€
Technology Transfer and Innovation
Economic Activity: 5.077.212€
- Basque Country: 0%
- National: 0%
- International: 0%
New Research Contracts 0
0 New Patent Applications
0 new patent:
- EPO: 3 532 058 B1
0 Licensing Agreement
Intellectual Property 2020
- 0 European Patent Applications
- 0 Trade Secret Application
- 0 USPTO Patent Application
- 0 Utility Model Application
Professional Career
- Motivation
- Management Career and Technical Staff
- Level 1
- Level 2A Level 2B
- Level 3
- Level 4
- Level 5
- Research Staff Career
- Level G1A Level G1B
- Level G2
- Level G3
- Level G4
- Flow chart-Professional Career Level
- Evaluation procedure to Management and Technical Staff
Organization Chart-Professional Career Level
Click on the image to see it enlarged in pdf
Equality Plan
Click on the image to see it enlarged in pdf
Competitive Funding
Private Funding
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
The new Scientific Advisory Board (SAB)
Scientific Advisory Board: Evaluation
SAB Meeting
September 28th to October 2nd
Strategic plan: Infrastructure
- Camera K2 cryoEM
- NMR 400 MHz
- NMR 600 MHz
- Vitrobot
- Single Cell
- Seahorse
- Biosafety Cabins (3)
- Plates reader
- Small equipment for the center
- Shaker-Incubator
- Animal Facility Washing machine & cages
- Flash chromatographer
- Glass case
- Nitrogen tank
- Microscope & SW
- New Brunswick Innova
- Rotatory evaporator
- Small equipment for the labs
IT servers, small computers, furniture for labs
Works at: Animal facility, Ground floor Labs at 801A
Renting for: Chromatograph, storage space for IT
Acquisition of 275 m2 at 800
Actions: New incorporation 2021
Mauro D'Amato
Monash University
Australia
Gastrointestinal Genomics lab
Genomic, computational and pre-clinical expertise to elucidate the pathogenetic mechanisms predisposing to gastrointestinal (GI) disease.
COVID Projects
Regional Funding
Desarrollo de herramientas analíticas para el diagnóstico serológico de la población general frente al SARS-CoV-2
Grant Amount 0 €
Desarrollo y validación de tests serológicos escalables para la identificación seropositivos frente COVID-19
Grant Amount 0 €
Desarrollo de un test rápido para la detección de anticuerpos frente a COVID-19 por sobreexpresión del antígeno inmunogénico viral (ARINTEST)
Grant Amount 0 €
Group Leaders
Nicola Abrescia, Oscar Millet, Asís Palazón, Juan Anguita, Jesús Jiménez-Barbero, Mikel Valle
Ramón y Cajal Program
Competitive Funding
Asís Palazón
Group Leader
Cancer Immunology and Immunotherapy Lab Espacio extra para maquetación html
Marco Piva
Ramón y Cajal Researcher
Cancer Cell Signaling & Metabolism Lab Espacio extra para maquetación html
IKERBASQUE
Competitive Funding
Ikerbasque Research Fellow
Marco Piva
Cancer Cell Signaling & Metabolism Lab
Isabel Mendizabal
Cancer Cell Signaling & Metabolism Lab
Ikerbasque Research Associates
Gonzalo Jiménez-Osés
Computational Chemistry Lab
Ana Ardá
Chemical Glycobiology Lab
International Foundations
Investigator: Gonzalo Jiménez-Osés
Addressing Enthalpy - Entropy Compensation in Carbohydrates Binding by Computation
European Funding
Juan Manuel Falcón
Plasma extracellular vesicles (EVs): the key for precision medicine in Glioblastoma - EV-glio
Coordinator
Italy
 |
 |
 |
 |
Rosa Barrio
PROTEOblood - Red cooperativa franco-española para el análisis de proteinopatías y el desarrollo de terapias individualizadas en cánceres hematológicos
Coordinator
Spain
Alfonso Martínez De La Cruz
For improving diagnostics and Grasping the disease mechanisms of rare Hypomagnesemia in patients with CNNM2 mutations - FIGHT - CNNM2
Coordinator
Netherlands
 |
 |
 |
 |
 |
Ashwin Woodhoo
ERC Consolidator Grant
MyeRIBO: Deconstructing the Translational Control of Myelination by Specialized Ribosomes
Applications
| Funding Entity |
Applications 19 Dec 2019 |
Applications 16 Dec 2020 |
| Basque Government | 17 | 17 |
| Ikerbasque | 3 | 5 |
| Spanish Ministry | 44 | 31 |
| ISCII | 4 | 2 |
| H2020 | 21 | 25 |
| National Entities | 52 | 78 |
| International Entities | 17 | 20 |
| Other International Calls | 7 | 3 |
| TOTAL | 165 | 181 |
2019
"2020
"Singular Projects
International
Special Networks
H2020: ERC
1 Advanced Grant
3 Starting Grants
2 Consolidator Grants
Publications
Citations
76
h-index
Scientific Highlights
Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives.
Linclau B, Ardá, Reichardt NC, Sollogoub M, Unione L, Vincent SP, Jiménez- Barbero J.
Chem Soc Rev. 2020 Jun 22,49(12):3863-3888. doi: 10.1039/c9cs00099b. PMID: 32520059.
The future of Extracellular Vesicles as Theranostics – an ISEV meeting report
Soekmadji C, Li B, Huang Y, Wang H, An T, Liu C, Pan W, Chen J, Cheung L, Falcon-Perez JM, Gho YS, Holthofer HB, Le MTN, Marcilla A, O'Driscoll L, Shekari F, Shen TL, Torrecilhas AC, Yan X, Yang F, Yin H, Xiao Y, Zhao Z, Zou X, Wang Q, Zheng L.
J Extracell Vesicles. 2020 Sep 4;9(1):1809766. doi: 10.1080/20013078.2020.1809766. PMID: 33144926; PMCID: PMC7580849.
Phosphoinositide 3-Kinase–Regulated Pericyte Maturation Governs Vascular Remodeling
Figueiredo AM, Villacampa P, Diéguez-Hurtado R, José Lozano J, Kobialka P, Cortazar AR, Martinez-Romero A, Angulo-Urarte A, Franco CA, Claret M, Aransay AM, Adams RH, Carracedo A, Graupera M.
Circulation. 2020 Aug 18,142(7):688-704. doi: 10.1161/CIRCULATIONAHA.119.042354. Epub 2020 May 29. PMID: 32466671.
Multiplex SERS Detection of Metabolic Alterations in Tumor Extracellular Media
Plou, J , Garcia, I, Charconnet, M, Astobiza, I, Garcia-Astrain, C , Matricardi, C, Mihi, A, Carracedo, A, Liz-Marzan, LM.
Advanced Functional Materials. 2020 Mar 5, 30 (17):Â 1910335Â Â doi: 10.1002/adfm.201910335.
The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development
Qureshi R, Picon-Ruiz M, Aurrekoetxea-Rodriguez I, Nunes de Paiva V, D'Amico M, Yoon H, Radhakrishnan R, Morata-Tarifa C, Ince T, Lippman ME, Thaller SR, Rodgers SE, Kesmodel S, Vivanco MDM, Slingerland JM. .
Cell Metab. 2020 Jun 2,31(6):1154-1172.e9. doi: 10.1016/j.cmet.2020.05.008. PMID: 32492394.
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly
Simon J, Nuñez-García M, Fernández-Tussy P, Barbier-Torres L, Fernández-Ramos D, Gómez-Santos B, Buqué X, Lopitz-Otsoa F, Goikoetxea-Usandizaga N, Serrano- Macia M, Rodriguez-Agudo R, Bizkarguenaga M, Zubiete-Franco I, Gutiérrez-de Juan V, Cabrera D, Alonso C, Iruzubieta P, Romero-Gomez M, van Liempd S, Castro A, Nogueiras R, Varela-Rey M, Falcón-Pérez JM, Villa E, Crespo J, Lu SC, Mato JM, Aspichueta P, Delgado TC, Martínez-Chantar ML. issmeyer, N; Coux, O; Rodriguez, MS; Barrio, R.
Cell Metab. 2020 Mar 3,31(3):605-622.e10. doi: 10.1016/j.cmet.2020.01.013. Epub 2020 Feb 21. PMID: 32084378, PMCID: PMC7259377.
Metabolic Landscape of the Mouse Liver by Quantitative 31P Nuclear Magnetic Resonance Analysis of the Phosphorome
Bernardo-Seisdedos G, Bilbao J, Fernández-Ramos D, Lopitz-Otsoa F, Gutierrez de Juan V, Bizkarguenaga M, Mateos B, Fondevila MF, Abril-Fornaguera J, Diercks T, Lu SC, Nogueiras R, Mato JM, Millet O.
Hepatology. 2020 Dec 7. doi: 10.1002/hep.31676. Epub ahead of print. PMID: 33284502.
Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer
Li Y, Lu L, Tu J, Zhang J, Xiong T, Fan W, Wang J, Li M, Chen Y, Steggerda J, Peng H, Chen Y, Li TWH, Zhou ZG, Mato JM, Seki E, Liu T, Yang H, Lu SC.
Hepatology. 2020 Nov;72(5):1682-1700. doi: 10.1002/hep.31196. Epub 2020 Oct 1. PMID: 32080887; PMCID: PMC7442711.
The L-α-Lysophosphatidylinositol/G Protein–Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis
Fondevila MF, Fernandez U, Gonzalez-Rellan MJ, Da Silva Lima N, Buque X, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hernández-Cosido L, Blanco Ó, Arab JP, Barrera F, Guallar D, Fidalgo M, López M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R.
Hepatology. 2021 Feb;73(2):606-624. doi: 10.1002/hep.31290. Epub 2020 Nov 13. PMID: 32329085; PMCID: PMC7894478.
Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3
de Las Rivas M, Paul Daniel EJ, Narimatsu Y, Compañón I, Kato K, Hermosilla P, Thureau A, Ceballos-Laita L, Coelho H, Bernadó P, Marcelo F, Hansen L, Maeda R, Lostao A, Corzana F, Clausen H, Gerken TA, Hurtado-Guerrero R.
Nat Chem Biol. 2020 Mar;16(3):351-360. doi: 10.1038/s41589-019-0444-x. Epub 2020 Jan 13. PMID: 31932717; PMCID: PMC7923394. Â
Dissecting the Essential Role of Anomeric β-Triflates in Glycosylation Reactions
Santana AG, Montalvillo-Jiménez L, Díaz-Casado L, Corzana F, Merino P, Cañada FJ, Jiménez-Osés G, Jiménez-Barbero J, Gómez AM, Asensio JL.
J Am Chem Soc. 2020 Jul 15;142(28):12501-12514. doi: 10.1021/jacs.0c05525. Epub 2020 Jul 6. PMID: 32579343.
Complete Dynamic Reconstruction of C60, C70, and (C59N)2 Encapsulation into an Adaptable Supramolecular Nanocapsule
García-Simón C, Colomban C, Çetin YA, Gimeno A, Pujals M, Ubasart E, Fuertes- Espinosa C, Asad K, Chronakis N, Costas M, Jiménez-Barbero J, Feixas F, Ribas X.
J Am Chem Soc. 2020 Sep 16;142(37):16051-16063. doi: 10.1021/jacs.0c07591. Epub 2020 Sep 3. PMID: 32822170.
Discovering Biomolecules with Huisgenase Activity: Designed Repeat Proteins as Biocatalysts for (3 + 2) Cycloadditions
Rivilla I, Odriozola-Gimeno M, Aires A, Gimeno A, Jiménez-Barbero J, Torrent- Sucarrat M, Cortajarena AL, Cossío FP.
J Am Chem Soc. 2020 Jan 15;142(2):762-776. doi: 10.1021/jacs.9b06823. Epub 2019 Dec 26. PMID: 31829573.8b13503 Â
An Epoxide Intermediate in Glycosidase Catalysis
Sobala LF, Speciale G, Zhu S, Raich L, Sannikova N, Thompson AJ, Hakki Z, Lu D, Shamsi Kazem Abadi S, Lewis AR, Rojas-Cervellera V, Bernardo-Seisdedos G, Zhang Y, Millet O, Jiménez-Barbero J, Bennet AJ, Sollogoub M, Rovira C, Davies GJ, Williams SJ.
ACS Cent Sci. 2020 May 27;6(5):760-770. doi: 10.1021/acscentsci.0c00111. Epub 2020 Apr 16. PMID: 32490192; PMCID: PMC7256955.
Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation
Gil de Montes E, Istrate A, Navo CD, Jiménez-Moreno E, Hoyt EA, Corzana F, Robina I, Jiménez-Osés G, Moreno-Vargas AJ, Bernardes GJL.
Angew Chem Int Ed Engl. 2020 Apr 6;59(15):6196-6200. doi: 10.1002/anie.201914529. Epub 2020 Feb 18. PMID: 31981460.
Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS- CoV-2 Spike Protein and their Interactions with Human Lectins
Lenza MP, Oyenarte I, Diercks T, Quintana JI, Gimeno A, Coelho H, Diniz A, Peccati F, Delgado S, Bosch A, Valle M, Millet O, Abrescia NGA, Palazón A, Marcelo F, Jiménez-Osés G, Jiménez-Barbero J, Ardá A, Ereño-Orbea J.
Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23763-23771. doi: 10.1002/anie.202011015. Epub 2020 Oct 22. PMID: 32915505; PMCID: PMC7894318.
Synthesis and Structural Analysis of Aspergillus fumigatus Galactosaminogalactans Featuring α-Galactose, α-Galactosamine and α-N-Acetyl Galactosamine Linkages
Zhang Y, Gómez-Redondo M, Jiménez-Osés G, Arda A, Overkleeft HS, van der Marel GA, Jiménez-Barbero J, Codée JDC.
Angew Chem Int Ed Engl. 2020 Jul 27;59(31):12746-12750. doi: 10.1002/anie.202003951. Epub 2020 May 20. PMID: 32342633.
Non-Stationary Complementary Non-Uniform Sampling (NOSCO NUS) for Fast Acquisition of Serial 2D NMR Titration Data.
Romero JA, Nawrocka EK, Shchukina A, Blanco FJ, Diercks T, Kazimierczuk K.
Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23496-23499. doi: 10.1002/anie.202009479. Epub 2020 Sep 29. PMID: 32852098; PMCID: PMC7756666.
Structure of the processive human Pol δ holoenzyme
Lancey C, Tehseen M, Raducanu VS, Rashid F, Merino N, Ragan TJ, Savva CG, Zaher MS, Shirbini A, Blanco FJ, Hamdan SM, De Biasio A.
Nat Commun. 2020 Feb 28;11(1):1109. doi: 10.1038/s41467-020-14898-6. PMID: 32111820; PMCID: PMC7048817.
Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila
Trastoy B, Naegeli A, Anso I, Sjögren J, Guerin ME.
Nat Commun. 2020 Sep 24;11(1):4844. doi: 10.1038/s41467-020-18696-y. PMID: 32973204; PMCID: PMC7518263.
Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
Barbier-Torres L, Fortner KA, Iruzubieta P, Delgado TC, Giddings E, Chen Y, Champagne D, Fernández-Ramos D, Mestre D, Gomez-Santos B, Varela-Rey M, de Juan VG, Fernández-Tussy P, Zubiete-Franco I, García-Monzón C, González-Rodríguez Á, Oza D, Valença-Pereira F, Fang Q, Crespo J, Aspichueta P, Tremblay F, Christensen BC, Anguita J, Martínez-Chantar ML, Rincón M.
Nat Commun. 2020 Jul 3;11(1):3360. doi: 10.1038/s41467-020-16991-2. PMID: 32620763; PMCID: PMC7334216.
Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides
Trastoy B, Du JJ, Klontz EH, Li C, Cifuente JO, Wang LX, Sundberg EJ, Guerin ME.
Nat Commun. 2020 Feb 14;11(1):899. doi: 10.1038/s41467-020-14754-7. PMID: 32060313; PMCID: PMC7021837.
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis
Palomo-Irigoyen M, Pérez-Andrés E, Iruarrizaga-Lejarreta M, Barreira-Manrique A, Tamayo-Caro M, Vila-Vecilla L, Moreno-Cugnon L, Beitia N, Medrano D, Fernández-Ramos D, Lozano JJ, Okawa S, Lavín JL, Martín-Martín N, Sutherland JD, de Juan VG, Gonzalez-Lopez M, Macías-Cámara N, Mosén-Ansorena D, Laraba L, Hanemann CO, Ercolano E, Parkinson DB, Schultz CW, Araúzo-Bravo MJ, Ascensión AM, Gerovska D, Iribar H, Izeta A, Pytel P, Krastel P, Provenzani A, Seneci P, Carrasco RD, Del Sol A, Martinez-Chantar ML, Barrio R, Serra E, Lazaro C, Flanagan AM, Gorospe M, Ratner N, Aransay AM, Carracedo A, Varela-Rey M, Woodhoo A.
J Clin Invest. 2020 Jul 1;130(7):3848-3864. doi: 10.1172/JCI130379. PMID: 32315290; PMCID: PMC7324187.
CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo
Alajati A, D'Ambrosio M, Troiani M, Mosole S, Pellegrini L, Chen J, Revandkar A, Bolis M, Theurillat JP, Guccini I, Losa M, Calcinotto A, De Bernardis G, Pasquini E, D'Antuono R, Sharp A, Figueiredo I, Nava Rodrigues D, Welti J, Gil V, Yuan W, Vlajnic T, Bubendorf L, Chiorino G, Gnetti L, Torrano V, Carracedo A, Camplese L, Hirabayashi S, Canato E, Pasut G, Montopoli M, Rüschoff JH, Wild P, Moch H, De Bono J, Alimonti A.
J Clin Invest. 2020 May 1;130(5):2435-2450. doi: 10.1172/JCI131133. PMID: 32250342; PMCID: PMC7190998.
Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
Hermanova I, Zúñiga-García P, Caro-Maldonado A, Fernandez-Ruiz S, Salvador F, Martín-Martín N, Zabala-Letona A, Nuñez-Olle M, Torrano V, Camacho L, Lizcano JM, Talamillo A, Carreira S, Gurel B, Cortazar AR, Guiu M, López JI, Martinez- Romero A, Astobiza I, Valcarcel-Jimenez L, Lorente M, Arruabarrena-Aristorena A, Velasco G, Gomez-Muñoz A, Suárez-Cabrera C, Lodewijk I, Flores JM, Sutherland JD, Barrio R, de Bono JS, Paramio JM, Trka J, Graupera M, Gomis RR, Carracedo A.
J Exp Med. 2020 Jun 1;217(6):e20191787. doi: 10.1084/jem.20191787. PMID: 32219437; PMCID: PMC7971141.
Modulation of immune responses using adjuvants to facilitate therapeutic vaccination
Schijns V, Fernández-Tejada A, Barjaktarović Ž, Bouzalas I, Brimnes J, Chernysh S, Gizurarson S, Gursel I, Jakopin Ž, Lawrenz M, Nativi C, Paul S, Pedersen GK, Rosano C, Ruiz-de-Angulo A, Slütter B, Thakur A, Christensen D, Lavelle EC.
Modulation of immune responses using adjuvants to facilitate therapeutic vaccination. Immunol Rev. 2020 Jul;296(1):169-190. doi: 10.1111/imr.12889. Epub 2020 Jun 28. PMID: 32594569; PMCID: PMC7497245.
OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models
Fabre M, Ferrer C, Domínguez-Hormaetxe S, Bockorny B, Murias L, Seifert O, Eisler SA, Kontermann RE, Pfizenmaier K, Lee SY, Vivanco MD, López-Casas PP, Perea S, Abbas M, Richter W, Simon L, Hidalgo M.
Clin Cancer Res. 2020 Jul 1;26(13):3420-3430. doi: 10.1158/1078-0432.CCR-19-2238. Epub 2020 Mar 11. PMID: 32161121.
COVID-19 Publications 
Abnormal concentration of porphyrins in serum from COVID-19 patient
San Juan I, Bruzzone C, Bizkarguenaga M, Bernardo-Seisdedos G, Laín A, Gil- Redondo R, Diercks T, Gil-Martínez J, Urquiza P, Arana E, Seco M, García de Vicuña A, Embade N, Mato JM, Millet O.
Br J Haematol. 2020 Sep;190(5):e265-e267. doi: 10.1111/bjh.17060. Epub 2020 Aug 29. Erratum in: Br J Haematol. 2021 Apr;193(2):429. PMID: 32745239; PMCID: PMC7436216.
SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum
Bruzzone C, Bizkarguenaga M, Gil-Redondo R, Diercks T, Arana E, García de Vicuña A, Seco M, Bosch A, Palazón A, San Juan I, Laín A, Gil-Martínez J, Bernardo-Seisdedos G, Fernández-Ramos D, Lopitz-Otsoa F, Embade N, Lu S, Mato JM, Millet O.
iScience. 2020 Oct 23;23(10):101645. doi: 10.1016/j.isci.2020.101645. Epub 2020 Oct 5. PMID: 33043283; PMCID: PMC7534591.
Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS- CoV-2 Spike Protein and their Interactions with Human Lectins
Lenza MP, Oyenarte I, Diercks T, Quintana JI, Gimeno A, Coelho H, Diniz A, Peccati F, Delgado S, Bosch A, Valle M, Millet O, Abrescia NGA, Palazón A, Marcelo F, Jiménez-Osés G, Jiménez-Barbero J, Ardá A, Ereño-Orbea J.
Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23763-23771. doi: 10.1002/anie.202011015. Epub 2020 Oct 22. PMID: 32915505; PMCID: PMC7894318.
Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points
Fondevila MF, Mercado-Gómez M, Rodríguez A, Gonzalez-Rellan MJ, Iruzubieta P, Valentí V, Escalada J, Schwaninger M, Prevot V, Dieguez C, Crespo J, Frühbeck G, Martinez-Chantar ML, Nogueiras R.
J Hepatol. 2021 Feb;74(2):469-471. doi: 10.1016/j.jhep.2020.09.027. Epub 2020 Oct 20. PMID: 33096086; PMCID: PMC7574841.
Scientific Response to the Coronavirus Crisis in Spain: Collaboration and Multidisciplinarity
Millet O, Cortajarena AL, Salvatella X, Kiessling LL, Jiménez-Barbero J.
ACS Chem Biol. 2020 Jul 17;15(7):1722-1723. doi: 10.1021/acschembio.0c00496. Epub 2020 Jun 25. PMID: 32584537; PMCID: PMC7323048.
Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals
Egia-Mendikute L, Bosch A, Prieto-Fernández E, Lee SY, Jiménez-Lasheras B, García Del Río A, Antoñana-Vildosola A, Bruzzone C, Bizkarguenaga M, Embade N, Gil-Redondo R, Martínez-Chantar ML, López-Hoyos M, Abrescia NGA, Mato JM, Millet Ó, Palazón A.
Commun Biol. 2021 Apr 20;4(1):486. doi: 10.1038/s42003-021-02011-6. PMID: 33879833; PMCID: PMC8058339.
Leveraging systems biology for predicting modulators of inflammation in patients with COVID-19
Jung S, Potapov I, Chillara S, Del Sol A.
Sci Adv. 2021 Feb 3;7(6):eabe5735. doi: 10.1126/sciadv.abe5735. PMID: 33536217.
Editorial Activity
-
-
Joaquín Castilla
Advisory Board
-
-
Óscar Millet
Associate Editor
-
-
Juan Anguita
Editor Board
-
-
Óscar Millet
Editor Board
-
-
Juan Anguita
Editor Board
-
-
Antonio Del Sol
Editor Board
-
-
Óscar Millet
Associate Editor
-
-
Óscar Millet
Editor Board
Jesús Jiménez-Barbero
Advisory Board
Jesús Jiménez-Barbero
Advisory Board
Jesús Jiménez-Barbero
Advisory Board
-
Félix Elortza
Editor Board
-
-
Juan M. Falcón
Review Editor
-
-
Rosa Barrio
Review Editor
-
-
Juan Anguita
Guest Associate Editor
Review Editor
-
-
Juan Anguita
Review Editor
-
-
Rosa Barrio
Associate Editor
-
-
Jesús Jiménez-Barbero
Associate Editor
-
-
Jesús Jiménez-Barbero
Advisory Board
-
-
Rosa Barrio
Editor Board
-
-
Juan Anguita
Senior Editor
-
-
Óscar Millet
Associate Editor
-
-
Félix Elortza
Editor Board
-
-
María Vivanco
Editor Board
-
Jesús Jiménez-Barbero
Advisory Board
-
Jesús Jiménez-Barbero
Advisory Board
Jesús Jiménez-Barbero
Advisory Board
Óscar Millet
Editor Board
Joaquín Castilla
Editor Board
Joaquín Castilla
Editor Board
Juan Anguita
Editor Board
PhD Thesis
0 in progress
Collaboration RVCTI
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
0 RVCTI
Accredited Centers Scientific Foundation AECC
Scientific Excellence
Quality, Impact and Leadership
PHASE I: Documentation
PHASE II: Visit to CIC bioGUNE
Telematics Assessment
October 14th and 15th, 2020
PHASE III: Membership of the Programme
Click on the image to see it enlarged in pdf
AAALAC Acreditation
AAALAC accredited Animal Facility
2008 AAALAC Accreditation
2011
2014
2017
2020
AAALAC Renewal of accreditation
Basque Research Alliance
 |
 |
 |
 |
|
 |
 |
 |
|
 |
 |
 |
 |
|
 |
 |
 |
 |
||
Provincial council of
 |
 |
 |
Scientific-technological commission
Socio-economic challenges: Personalized health (coordination)
Degree in Medicine.
University of Deusto
Battalion of the imposition of robes. 1st Student Promotion.
Start in January:
24 Teachers
MATERIA M3
Chemistry Applied to Life Sciences
MATERIA M4
Homeostasis and Regulation
Health Crisis: COVID-19
ISCIII validation for performing PCR tests
Click on the image to see it enlarged in pdf
COVID-19 research projects
The first aims to validate and develop rapid virological diagnostic techniques for SARS-CoV-2. Different spike protein antigens have been generated, which have been validated in ELISA tests. Monoclonal antibodies are being generated.
Nicola Abrescia
Structure & Cell Biology of Viruses
Óscar Millet
Precision Medicine & Metabolism
Juan Anguita
Inflammation & Macrophage Plasticity
Mikel Valle
CryoEM of Biological Macromolecules
-
June Ereño-Orbea & Jesús Jiménez-Barbero
Chemical Glycobiology
Asís Palazón
Cancer Immunology & Immunotherapy
An effective process has been developed for sample processing, RNA purification and detection of the RNA of the virus by PCR. Various laboratory procedures have been validated for automated RNA extraction in human samples, as well as virus RNA detection procedures using PCR, in collaboration with the Arquimea group (webcovid19). Saliva from positive individuals also works with the antigen test (Abbott). The sample left after this test can be used to extract RNA and detect SARS-CoV-2 with the bioGUNE CIC procedure.
Ana M. Aransay
Genome Analysis Platform
-
Arkaitz Carracedo & Edurne Berra
Cancer Cell Signaling & Metabolism
Joaquín Castilla
Prion Research
Metabolic disorders affecting the composition of lipoproteins and metabolites have been identified in the serum of COVID-19 patients
Óscar Millet
Precision Medicine & Metabolism
A fourth project is aimed at the application of new computational methods to characterize the immune response that defines this pathology and to propose strategies and treatments that are able to modulate the corresponding severe inflammatory cascade.
Antonio del Sol
Computational Biology
Another project, led by CIMUS with the participation of bioGUNE, has determined that the fatty liver with inflammation (NASH) favors the entry of coronavirus into this organ in obese people.
Malu Martínez-Chantar
Liver Disease
These projects are being developed in collaboration with different Institutions and agents:
 |
 |
 |
|
|
|
|
 |
Health Crisis:
CIC bioGUNE in COVID-19
Click on the image to see it enlarged in pdf
Business Development Activity
R&D agreements with companies
COVID 19
Production of Antigens and Monoclonal Antibodies for rapid and effective diagnosis of COVID-19
Collaboration agreement
Technology Transfer and Innovation
Business Development
Business Leads generation:
- 0 new business leads
- 0 MTA
- 0 CDA signed with companies
- 0 Collaborative Agreements
- 0 Sponsorship Agreements
- 0 Licenses Options
- 0 Industrial Doctorate
Training
InnoBerrIkasi
BioBridge
The program provides PhD and MBA students a vehicle toward entrepreneurship through learn-by-doing methodology, at the intersection of Life Sciences, Engineering and Business.
TechBoost
We continuously screen for technologies with high exploitation values for society and scientists are immersed in the development and evaluation of the idea and the generation of models to allow commercialization.
Technology Certifications
NMR-based Diagnostics
ISO 9001 obtained
Diagnostic analysis of metabolites from blood and urine. Capacity 15.000 samples/year. Collaboration with Bruker.
New Spin-Off Company:
Akribea 6174 S.L.
September 18th, 2020
- Acquisition and filtering of databases in the context of precision medicine
- Statistical data processing and processing to establish tools to support the diagnosis of pathologies
- Acquisition and processing of NMR data and their applications
Society Outreach
Approach Civil Society
Collaboration Agreements
Enhance External Visibility
Social Media
@CICbioGUNE
CIC bioGUNE Bilbao
CIC bioGUNE
CIC bioGUNE
Create an Alumni Network
In collaboration with Bizkaia Talent:
The talent attraction /retention arm of Basque Country
Highlights
CIC bioGUNE investigators publish more than 160 publications in 2020. More than 30 % of them display an Impact factor above 10. CIC publications are cited more than 7400 times in 2020.
CIC bioGUNE investigators file 7 EPO and 1 PCT applications.
CIC bioGUNE researchers are awarded with 28 new competitive R+D projects, funded by public and private institutions. 85 R+D projects are running along 2020.
Gonzalo Jiménez-Osés (Group Leader, Computational Chemistry Lab) and Ana Ardá (Associated Principal Investigator, Chemical Glycobiology lab) are promoted to Ikerbasque Research Associates.
CIC bioGUNE is recognized as "Centro de la RED de Centros FAECC”, by the Foundation of the Spanish Association Against Cancer".
CIC bioGUNE keeps its position within the top 100 NPO/NGO Institutions worldwide (position 48) in Life Sciences, according to Nature Index.
The External Scientific Advisory Board visits virtually CIC bioGUNE to carry out the corresponding evaluation of the Center and the Research Groups. Drs. Marisol Soengas (CNIO, Madrid), Caroline Dive (Cancer Research UK, Manchester), and María José Alonso (Santiago de Compostela, CIMUS) join the SAB by the end of the year.
17 PhD Thesis are presented by CIC bioGUNE ESRs along 2020.
CIC bioGUNE continues with its strategic plan to keep the key infrastructures: new actions in the NMR, proteomics, and cryoEM platforms are carried out, together with the update of the animal facility and the establishment of a life-cell image facility.
Competitive funding at CIC bioGUNE reaches 67,6% of total funding. Private funding goes beyond 30% of total funding.
CIC bioGUNE keeps its working capacity during the pandemic, establishing a specific plan that combines responsibility, safety, and focused research. Five specific collaborative projects on COVID-19, integrating 12 CIC bioGUNE research groups and different institutions and agents, are developed during 2020.
Despite the pandemic, the introductory week (October 5-9) for the new Early Stage Researchers(ESR) at CIC bioGUNE is delivered on line with great success. funding.
A new Equality Plan is established.
A new spin-off company, Akribea 6174 SL, is launched by CIC bioGUNE investigators, in the context of NMR and precision medicine.
Video Outreach
Training – ESR
The CIC bioGUNE Advanced Training Program
Introductory week: 5-9 October
Recognitions
Press
Radio & TV
- 20.06.02 Interview with Oscar Millet and June Ereño-Orbea on new therapeutic strategies for autoimmune diseases and cancer.
- 20.09.08 Interview with Jose M. Mato, Oscar Millet, Ana María Aransay and Arkaitz Carracedo on COVID-19.
- 20.11.16 Interview with José M. Mato and Oscar Millet on patronage activities and ongoing investigations.
- 20.07.07 Interview with Malu Martínez Chantar on the GalNAC-MCJ molecule.
- 20.08.19 Interview with Oscar Millet on publication in the British Journal of Hematology.
- 20.11.10 Interview with Donatello Castellana on statement of patronage activities.
- 20.06.30 Interview with Ashwin Woodhoo on research that opens pathways to treat nervous system cancer.
- 20.11.17 Interview with Arkaitz Carracedo on statement of patronage activities.
- 20.08.14 Interview with Oscar Millet on publication in the British Journal of Hematology.
- 20.11.05 Interview with Oscar Millet on research at COVID-19.
- 20.11.10 Interview with Oscar Millet on statement of patronage activities.
- 20.06.30 Interview with Ashwin Woodhoo on research that opens pathways to treat nervous system cancer.
- 20.10.21 Interview with Oscar Millet on the publication on COVID-19.
- 20.09.24 Interview with Arkaitz Carracedo on World Cancer Day.
Activities
Outreach
