Activity Report 2019
Activity Report 2019
About Us
Mission:
Conducting research of excellence in the field of the life sciences, covering the entire value of R&D&i, including technology transfer and commercial exploitation of the generated scientific results.
Strategic Challenges:
- Research of excellence
- Technology Transfer
- Collaboration with RVCTI agents
- International recognition
- Training and promotion of research talent
- Attraction and retention of talent
- Communication and Outreach
- Excellence in Management
Strategy:
Commitment to specialization and excellence
Competitiveness:
- Leading infrastructures
- Human Resources
- Technical and administrative support
- Competitive salaries
- Goal-Fulfillment Incentives
Staff
Staff 2019.12.31: 0
Average Age: 0 years
Permanent staff: 0 (44%)
Gender distribution
-
0% Female
120 -
0% Male
91 -
0% LISM - Law of Social Integration of the Handicapped
4
211 Total CIC bioGUNE Personnel
-
0% Research
178 -
0% Administration and Services
33
Researchers Distribution by Proffesional Category
| nº | % |  |
 |
||
| Researchers | 126 | 71.2 | 63 | 63 | |
| • Principal investigators/Platform Managers | 27 | 15.3 | 7 | 20 | |
| • Postdoctoral Researchers/Research Assistants | 44 | 24.9 | 24 | 20 | |
| • PhD Students | 55 | 31.1 | 32 | 23 | |
| Technicians | 51 | 28.8 | 36 | 15 |
Research Distribution by Geographic Origin
Research Distribution by Geographic Origin
-
0% Spain
90 researchers -
0% Rest of Europe
23 researchers -
0% The Americas
10 researchers -
0% Asia
3 researchers
Strategic Plan
New incorporations
Dr. Gonzalo Jiménez-Osés
University of La Rioja
Spain
Dr. Asís Palazón
University of Cambridge & Astra Zeneca
United Kingdom
Training
0 Trabajos Fin de Grado
0 Trabajos fin de Máster
0 Erasmus
0 Formación Profesional
0 Prácticas Formativas de Grado
Applications
| Funding Organism | Programme | Requests |
| Ministry of Science, Innovation and Universities |
Programa Estatal de Promoción del Talento y su Empleabilidad en I+D+i | 21 |
| Programa Estatal de Generación de Conocimiento y Fortalecimiento Científico y Tecnológico del Sistema de I+D+i | 12 | |
| Programa Estatal de I+D+i Orientada a los Retos de la Sociedad | 11 | |
| ISCIII | Programación Conjunta Internacional | 2 |
| Proyectos de Desarrollo Tecnológico en Salud | 1 | |
| Incorporación de nuevos grupos al consorcio CIBER | 1 | |
| Basque Government | Ayudas a la Investigación Colaborativa – Programa ELKARTEK | 5 |
| Ayudas a proyectos de investigación y desarrollo en salud | 4 | |
| Programa Predoctoral y Postdoctoral/Programa Bikaintek | 6 | |
| Adquisición Equipamiento Científico | 1 | |
| BIND 4. 0. Accelerator Program | 1 | |
| Ikerbasque | Ikerbasque Research Fellow | 3 |
| UE-H2020 | MSCActions | 16 |
| European Research Council (Starting G/Consolidator G/PoC G) | 4 | |
| FET-OPEN | 1 | |
| National Private Organisms |
Fundación Bancaria “la Caixa” | 24 |
| Fundación Científica AECC | 4 | |
| Fundación BBVA | 5 | |
| Fundación Merck Salud | 3 | |
| Fundación Domingo Martínez | 1 | |
| Fundación FERO | 1 | |
| Fundación CRIS | 2 | |
| La Marató de TV3 | 1 | |
| Fundación Francisco Cobos | 2 | |
| Fundación Banco Sabadell | 2 | |
| Fundación Jesús Gangoiti Barrera | 3 | |
| GETECCU | 1 | |
| Ship2B | 1 | |
| Fundación Tatiana Pérez Guzmán el Bueno | 2 | |
| International Private Organisms |
Gilead Science | 2 |
| Worldwide cancer research AICR | 2 | |
| World Cancer Research | 1 | |
| European Institute of Technology (EIT Health) | 1 | |
| EASI Genomics | 1 | |
| Chan Zuckerberg Initiative | 1 | |
| Swiss Cancer Research Foundation | 1 | |
| TAKEDA Oncology | 1 | |
| Ferring Research Institute | 1 | |
| Inospin | 1 | |
| March of Dimes | 1 | |
| Michael J. Fox Foundation | 1 | |
| Pfizer Foundation | 1 | |
| L´ORÉAL-UNESCO | 1 | |
| EMBO Long-term Fellowship | 1 | |
| Joint Traditional Calls | Rare Disease E-Rare/ERAPerMed/ERA-Net NEURON | 5 |
| INTERREG | POCTEFA/SUDOE | 2 |
Applications
0
New Calls
H2020-UE → ⇧1
FET-OPEN
National Private Organisms → ⇧5
 |
 |
 |
 |
Fundación Jesús Gangoiti Barrera |
International Private Organisms → ⇧10
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
Funding
Total 2019 R&D Budget: 0 k€
R&D Projects: 0
New R&D Projects: 0
- 0 % Competitive public Funding
- 0 % Non competitive public funding
- Total: 0% competitive + 0% non-competitive
-
0 % Basque Government Departments
7.795 K€ -
0 % MINECO & MEDC (Spanish Government)
3.506 K€ -
0 % R&D Contracts, Research Services & Others
5.761 K€ -
0 % EU & International Projects
2.044 K€
Publications
Citations
8
Av. IF
Technology Transfer and Innovation
Economic Activity: 5.103.252 €
- Basque Country: 0%
- National: 0%
- International: 0%
New Research Contracts 0
0 New Patent Applications
0 new patent:
- USPTO: 10,420,755
0 Licensing Agreement
12 New Patent Applications
- 0 European Patent Applications
- 0 PCT Patent Applications
- 0 USPTO Patent Applications
- 0 Other Patent Applications
NMR-based Diagnostic
Diagnostic analysis of metabolites from blood and urine. Capacity 15. 000 samples/year. Collaboration with Bruker. ISO13485 in process.
AAV Quality Control
Adeno associated viruses used in gene therapy need quality control to check for Empty vs Full Capsid. Microscopy fulfills the industry requirement by returning critical data on AAV charges ISO9001 in process.
Highlights
CIC bioGUNE investigators obtain two new ERC Grants in 2019:
- ERC Consolidator Grant - Arkaitz Carracedo. CancerADAPT - Targeting the adaptive capacity of prostate cancer through the manipulation of transcriptional and metabolic traits.
- ERC Starting Grant - Asis Palazon. NextGen IO - Exploiting the hypoxia response in T cells for Next-Generation Immuno-Oncology.
One new lab (Precision Medicine & Metabolism) is created by merging two of the existing ones.
Two new research groups (Cancer Immunology & Immunotherapy and Computational Chemistry) join CIC bioGUNE.
CIC bioGUNE publish more than 180 publications in 2019. More than 30% of them display an Impact factor above 10. The average IF in 2019 reaches 8. CIC publications are cited more than 5000 times in 2019.
A new IVDR NMR 600 MHz spectrometer is purchased to further support the NMR ICTS and extend the NMR & Metabolomics projects developed at CIC bioGUNE.
CIC bioGUNE is recognized within the top 100 NPO/NGO Institutions worldwide (position 62) in Life Sciences, according to Nature Index.
Competitive funding at CIC bioGUNE reaches 66% of total funding. Private funding goes beyond 35% of total funding.
Scientific Highlights
Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects
de Soysa, TY; Ranade, SS; Okawa, S; Ravichandran, S; Huang, Y; Salunga, HT; Schricker, A; del Sol, A; Gifford, CA; Srivastava, D.
Nature. Volume / Issue / Pages:572(7767):120-124. DOi: 10. 1038/s41586-019-1414-x
Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain
Kalamakis, G; Brune, D; Ravichandran, S; Bolz, J; Fan, WQ; Ziebell, F; Stiehl, T; Catala-Martinez, F; Kupke, J; Zhao, S; Llorens-Bobadilla, E; Bauer, K; Limpert, S; Berger, B; Christen, U; Schmezer, P; Mallm, JP; Berninger, B; Anders, S; del Sol, A; Marciniak-Czochra, A; Martin-Villalba, A.
Cell. Volume / Issue / Pages:176(6):1407-+. DOi: 10. 1016/j. cell. 2019. 01. 040
Assessment of network module identification across complex diseases
Choobdar, S; Ahsen, ME; Crawford, J; Tomasoni, M; Fang, T; Lamparter, D; Lin, JY; Hescott, B; Hu, XZ; Mercer, J; Natoli, T; Narayan, R; Aicheler, F; Amoroso, N; Arenas, A; Azhagesan, K; Baker, A; Banf, M; Batzoglou, S; Baudot, A; Bellotti, R; Bergmann, S; Boroevich, KA; Brun, C; Cai, S; Caldera, M; Calderone, A; Cesareni, G; Chen, WQ; Chichester, C; Cowen, L; Cui, HZ; Dao, P; De Domenico, M; Dhroso, A; Didier, G; Divine, M; del Sol, A; Feng, XY; Flores-Canales, JC; Fortunato, S; Gitter, A; Gorska, A; Guan, YF; Guenoche, A; Gomez, S; Hamza, H; Hartmann, A; He, S; Heijs, A; Heinrich, J; Hu, Y; Huang, XQ; Hughitt, VK; Jeon, M; Jeub, L; Johnson, NT; Joo, K; Joung, I; Jung, S; Kalko, SG; Kamola, PJ; Kang, J; Kaveelerdpotjana, B; Kim, M; Kim, YA; Kohlbacher, O; Korkin, D; Krzysztof, K; Kunji, K; Kutalik, Z; Lage, K; Lang-Brown, S; Le, TD; Lee, J; Lee, S; Lee, J; Li, D; Li, JY; Liu, L; Loizou, A; Luo, ZH; Lysenko, A; Ma, TL; Mall, R; Marbach, D; Mattia, T; Medvedovic, M; Menche, J; Micarelli, E; Monaco, A; Mueller, F; Narykov, O; Norman, T; Park, S; Perfetto, L; Perrin, D; Pirro, S; Przytycka, TM; Qian, XN; Raman, K; Ramazzotti, D; Ramsahai, E; Ravindran, B; Rennert, P; Saez-Rodriguez, J; Scharfe, C; Sharan, R; Shi, N; Shin, W; Shu, H; Sinha, H; Slonim, DK; Spinelli, L; Srinivasan, S; Subramanian, A; Suver, C; Szklarczyk, D; Tangaro, S; Thiagarajan, S; Tichit, L; Tiede, T; Tripathi, B; Tsherniak, A; Tsunoda, T; Turei, D; Ullah, E; Vahedi, G; Valdeolivas, A; Vivek, J; von Mering, C; Waagmeester, A; Wang, B; Wang, YJ; Weir, BA; White, S; Winkler, S; Xu, K; Xu, TS; Yan, CH; Yang, LQ; Yu, KX; Yu, XT; Zaffaroni, G; Zaslavskiy, M; Zeng, T; Zhang, JTD; Zhang, L; Zhang, WJ; Zhang, L; Zhang, XY; Zhang, JP; Zhou, X; Zhou, JR; Zhu, HT; Zhu, JJ; Zuccon, G; Stolovitzky, G; Kutalik, Z; Lage, K; Slonim, DK; Saez-Rodriguez, J; Cowen, LJ; Bergmann, S; Marbach, D.
Nature methods. Volume / Issue / Pages:16(9):843-+. DOi: 10. 1038/s41592-019-0509-5
Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program
Janin, M; Ortiz-Barahona, V; de Moura, MC; Martinez-Cardus, A; Llinas-Arias, P; Soler, M; Nachmani, D; Pelletier, J; Schumann, U; Calleja-Cervantes, ME; Moran, S; Guil, S; Bueno-Costa, A; Pineyro, D; Perez-Salvia, M; Rossello-Tortella, M; Pique, L; Bech-Serra, JJ; De la Torre, C; Vidal, A; Martinez-Iniesta, M; Martin-Tejera, JF; Villanueva, A; Arias, A; Cuartas, I; Aransay, AM; La Madrid, AM; Carcaboso, AM; Santa-Maria, V; Mora, J; Fernandez, AF; Fraga, MF; Aldecoa, I; Pedrosa, L; Graus, F; Vidal, N; Martinez-Soler, F; Tortosa, A; Carrato, C; Balana, C; Boudreau, MW; Hergenrother, PJ; Kotter, P; Entian, KD; Hench, J; Frank, S; Mansouri, S; Zadeh, G; Dans, PD; Orozco, M; Thomas, G; Blanco, S; Seoane, J; Preiss, T; Pandolfi, PP; Esteller, M.
Acta Neuropathologica. Volume / Issue / Pages:138(6):1053-1074. DOi: 10. 1007/s00401-019-02062-4
Plasticity of adult hepatocytes and readjustment of cell fate: a novel dogma in liver disease
Cubero, FJ; Martinez-Chantar, ML.
Gut. Volume / Issue / Pages:68(6):954-956. DOi: 10. 1136/gutjnl-2019-318218
Using Ubiquitin Binders to Desipher the Ubiquitin Code
Mattern, M; Sutherland, J; Kadimisetty, K; Barrio, R; Rodriguez, MS.
Trends in biochemical sciences. Volume / Issue / Pages:44(7):599-615. DOi: 10. 1016/j. tibs. 2019. 01. 011
PROTEOSTASIS: A European Network to Break Barriers and Integrate Science on Protein Homeostasis
Dissmeyer, N; Coux, O; Rodriguez, MS; Barrio, R.
Trends in biochemical sciences. Volume / Issue / Pages:44(5):383-387. DOi: 10. 1016/j. tibs. 2019. 01. 007
Methionine Adenosyltransferase alpha 1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression
Murray, B; Peng, H; Barbier-Torres, L; Robinson, AE; Li, TWH; Fan, W; Tomasi, ML; Gottlieb, RA; Van Eyk, J; Lu, ZM; Martinez-Chantar, ML; Liangpunsakul, S; Skill, NJ; Mato, JM; Lu, SC.
Hepatology . Volume / Issue / Pages:70(6):2018-2034. DOi: 10. 1002/hep. 30762
Causes of hOCT1-Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor-Selective Gene Therapy
Lozano, E; Macias, RIR; Monte, MJ; Asensio, M; del Carmen, S; Sanchez-Vicente, L; Alonso-Pena, M; Al-Abdulla, R; Munoz-Garrido, P; Satriano, L; O'Rourke, CJ; Banales, JM; Avila, MA; Martinez-Chantar, ML; Andersen, JB; Briz, O; Marin, JJG.
Hepatology . Volume / Issue / Pages:70(4):1261-1246. DOi: 10. 1002/hep. 30656
Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis
Banales, JM; Inarrairaegui, M; Arbelaiz, A; Milkiewicz, P; Muntane, J; Munoz-Bellvis, L; La Casta, A; Gonzalez, LM; Arretxe, E; Alonso, C; Martinez-Arranz, I; Lapitz, A; Santos-Laso, A; Avila, MA; Martinez-Chantar, ML; Bujanda, L; Marin, JJG; Sangro, B; Macias, RIR.
Hepatology . Volume / Issue / Pages:70(2):547-562. DOi: 10. 1002/hep. 30319
Fine-Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease
Blokker, BA; Maijo, M; Echeandia, M; Galduroz, M; Patterson, AM; Ten, A; Philo, M; Schungel, R; Gutierrez-de Juan, V; Halilbasic, E; Fuchs, C; Le Gall, G; Milkiewicz, M; Milkiewicz, P; Banales, JM; Rushbrook, SM; Mato, JM; Trauner, M; Muller, M; Martinez-Chantar, ML; Varela-Rey, M; Beraza, N.
Hepatology . Volume / Issue / Pages:69(2):699-716. DOi: 10. 1002/hep. 30275
Impact of Aromatic Stacking on Glycoside Reactivity: Balancing CH/pi and Cation/pi Interactions for the Stabilization of Glycosyl-Oxocarbenium Ions
Montalvillo-Jimenez, L; Santana, AG; Corzana, F; Jimenez-Oses, G; Jimenez-Barbero, J; Gomez, AM; Asensio, JL.
Journal of the American Chemical Society. Volume / Issue / Pages:141(34):13372-13384. DOi: 10. 1021/jacs. 9b03285
Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage
Companon, I; Guerreiro, A; Mangini, V; Castro-Lopez, J; Escudero-Casao, M; Avenoza, A; Busto, JH; Castillon, S; Jimenez-Barbero, J; Asensio, JL; Jimenez-Oses, G; Boutureira, O; Peregrina, JM; Hurtado-Guerrero, R; Fiammengo, R; Bernardes, GJL; Corzana, F.
Journal of the American Chemical Society. Volume / Issue / Pages:141(9):4063-4072. DOi: 10. 1021/jacs. 8b13503
Computational Strategies for Niche-Dependent Cell Conversion to Assist Stem Cell Therapy
Sol, A; Okawa, S; Ravichandran, S.
Trends in biotechnology. Volume / Issue / Pages:37(7):687-696. DOi: 10. 1016/j. tibtech. 2019. 01. 005
Glycoprofile Analysis of an Intact Glycoprotein As Inferred by NMR Spectroscopy
Unione, L; Lenza, MP; Arda, A; Urquiza, P; Lain, A; Falcon-Perez, JM; Jimenez-Barbero, J; Millet, O.
ACS central science. Volume / Issue / Pages:5(9):1554-1561. DOi: 10. 1021/acscentsci. 9b00540
Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction
Zhang, QJ; Gimeno, A; Santana, D; Wang, Z; Valdes-Balbin, Y; Rodriguez-Noda, LM; Hansen, T; Kong, L; Shen, MJ; Overkleeft, HS; Verez-Bencomo, V; van der Marel, GA; Jimenez-Barbero, J; Chiodo, F; Codee, JDC.
ACS central science. Volume / Issue / Pages:5(8):1407-1416. DOi: 10. 1021/acscentsci. 9b00454
Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification
Lindstedt, PR; Aprile, FA; Matos, MJ; Perni, M; Bertoldo, JB; Bernardim, B; Peter, Q; Jimenez-Oses, G; Knowles, TPJ; Dobson, CM; Corzana, F; Vendruscolo, M; Bernardes, GJL.
ACS central science. Volume / Issue / Pages:5(8):1417-1424. DOi: 10. 1021/acscentsci. 9b00467
Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2
Klontz, EH; Trastoy, B; Deredge, D; Fields, JK; Li, C; Orwenyo, J; Marina, A; Beadenkopf, R; Gunther, S; Flores, J; Wintrode, PL; Wang, LX; Guerin, ME; Sundberg, EJ.
ACS central science. Volume / Issue / Pages:5(3):524-538. DOi: 10. 1021/acscentsci. 8b00917
Structural and Computational Analysis of 2-Halogeno-Glycosyl Cations in the Presence of a Superacid: An Expansive Platform
Lebedel, L; Arda, A; Martin, A; Desire, J; Mingot, A; Aufiero, M; Aiguabella, N; Gilmour, R; Jimenez-Barbero, J; Bleriot, Y; Thibaudeau, S.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. Volume / Issue / Pages:58(39):13758-13762. DOi: 10. 1002/anie. 201907001
Minimizing the Entropy Penalty for Ligand Binding: Lessons from the Molecular Recognition of the Histo Blood-Group Antigens by Human Galectin-3
Gimeno, A; Delgado, S; Valverde, P; Bertuzzi, S; Berbis, MA; Echavarren, J; Lacetera, A; Martin-Santamaria, S; Surolia, A; Canada, FJ; Jimenez-Barbero, J; Arda, A.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. Volume / Issue / Pages:58(22):7268-7272. DOi: 10. 1002/anie. 201900723
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation
Matos, MJ; Navo, CD; Hakala, T; Ferhati, X; Guerreiro, A; Hartmann, D; Bernardim, B; Saar, KL; Companon, I; Corzana, F; Knowles, TPJ; Jimenez-Oses, G; Bernardes, GJL.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. Volume / Issue / Pages:58(20):6640-6644. DOi: 10. 1002/anie. 201901405
Surface Attachment Enhances the Thermodynamic Stability of ProteinL
Ortega, G; Kurnik, M; Dauphin-Ducharme, P; Li, H; Arroyo-Curras, N; Caceres, A; Plaxco, KW.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. Volume / Issue / Pages:58(6):1714-1718. DOi: 10. 1002/anie. 201812231
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
Canal-Martin, A; Sastre, J; Sanchez-Barrena, MJ; Canales, A; Baldominos, S; Pascual, N; Martinez-Gonzalez, L; Molero, D; Fernandez-Valle, ME; Saez, E; Blanco-Gabella, P; Gomez-Rubio, E; Martin-Santamaria, S; Saiz, A; Mansilla, A; Canada, FJ; Jimenez-Barbero, J; Martinez, A; Perez-Fernandez, R.
Nature Communications. Volume / Issue / Pages:10(1):2798-. DOi: 10. 1038/s41467-019-10627-w
Discovery of processive catalysis by an exo-hydrolase with a pocket-shaped active site
Streltsov, VA; Luang, S; Peisley, A; Varghese, JN; Cairns, JRK; Fort, S; Hijnen, M; Tvaroska, I; Arda, A; Jimenez-Barbero, J; Alfonso-Prieto, M; Rovira, C; Mendoza, F; Tiessler-Sala, L; Sanchez-Aparicio, JE; Rodriguez-Guerra, J; Lluch, JM; Marechal, JD; Masgrau, L; Hermova, M.
Nature Communications. Volume / Issue / Pages:10(2222):-. DOi: 10. 1038/s41467-019-09691-z
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
Escobedo, A; Topal, B; Kunze, MBA; Aranda, J; Chiesa, G; Mungianu, D; Bernardo-Seisdedos, G; Eftekharzadeh, B; Gairi, M; Pierattelli, R; Felli, IC; Diercks, T; Millet, O; Garcia, J; Orozco, M; Crehuet, R; Lindorff-Larsen, K; Salvatella, X.
Nature communications. Volume / Issue / Pages:10(1):2034-. DOi: 10. 1038/s41467-019-09923-2
Structural basis for assembly of vertical single beta-barrel viruses
Santos-Perez, I; Charro, D; Gil-Carton, D; Azkargorta, M; Elortza, F; Bamford, DH; Oksanen, HM; Abrescia, NGA.driguez-Guerra, J; Lluch, JM; Marechal, JD; Masgrau, L; Hermova, M.
Nature communications. Volume / Issue / Pages:10():-. DOi: 10. 1038/s41467-019-08927-2
Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo
Pena-Jimenez, D; Fontenete, S; Megias, D; Fustero-Torre, C; Grana-Castro, O; Castellana, D; Loewe, R; Perez-Moreno, M.
EMBO JOURNAL. Volume / Issue / Pages:38(19):-. DOi: 10. 15252/embj. 2019101688
A general computational approach to predicting synergistic transcriptional cores that determine cell subpopulation identities
Okawa, S; del Sol, A.
Nucleic acids research. Volume / Issue / Pages:47(7):3333-3343. DOi: 10. 1093/nar/gkz147
An integrative method to predict signalling perturbations for cellular transitions
Zaffaroni, G; Okawa, S; Morales-Ruiz, M; del Sol, A.
Nucleic acids research. Volume / Issue / Pages:47(12):e72-. DOi: 10. 1093/nar/gkz232
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
Pabis, M; Popowicz, GM; Stehle, R; Fernandez-Ramos, D; Asami, S; Warner, L; Garcia-Maurino, SM; Schlundt, A; Martinez-Chantar, ML; Diaz-Moreno, I; Sattler, M.
Nucleic acids research. Volume / Issue / Pages:47(2):1011-1029. DOi: 10. 1093/nar/gky1138
Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles
Clayton, A; Boilard, E; Buzas, EI; Cheng, L; Falcon-Perez, JM; Gardiner, C; Gustafson, D; Gualerzi, A; Hendrix, A; Hoffmann, A; Jones, J; Lasser, C; Lawson, C; Lenassi, M; Nazarenko, I; O'Driscoll, L; Pink, R; Siljander, PRM; Soekmadji, C; Wauben, M; Welsh, JA; Witwer, K; Zheng, L; Nieuwland, R.
Journal of Extracellular Vesicles. Volume / Issue / Pages:8(1):-. DOi: 10. 1080/20013078. 2019. 1647027
Tetraspanin-decorated extracellular vesicle-mimetics as a novel adaptable reference material
Lozano-Andres, E; Libregts, SF; Toribio, V; Royo, F; Morales, S; Lopez-Martin, S; Vales-Gomez, M; Reyburn, HT; Falcon-Perez, JM; Wauben, MH; Soto, M; Yanez-Mo, M.
Journal of Extracellular Vesicles. Volume / Issue / Pages:8(1):1573052-. DOi: 10. 1080/20013078. 2019. 1573052
Differences in the metabolite composition and mechanical properties of extracellular vesicles secreted by hepatic cellular models
Royo, F; Gil-Carton, D; Gonzalez, E; Mleczko, J; Palomo, L; Perez-Cormenzana, M; Mayo, R; Alonso, C; Falcon-Perez, JM.
Journal of Extracellular Vesicles. Volume / Issue / Pages:8(1):-. DOi: 10. 1080/20013078. 2019. 1575678
Reply to: Retesting the influences of mutation accumulation and antagonistic pleiotropy on human senescence and disease
Rodriguez, JA; Farre, X; Muntane, G; Marigorta, UM; Hughes, DA; Spataro, N; Bosch, E; Navarro, A.
Nature ecology & evolution. Volume / Issue / Pages:3(7):994-995. DOi: 10. 1038/s41559-019-0926-y
Arkaitz Carracedo: If the scientific question is good, the result will be interesting
Houston, S; Carracedo, A.
JOURNAL OF EXPERIMENTAL MEDICINE. Volume / Issue / Pages:216(11):2449-2450. DOi: 10. 1084/jem. 20191880
Draft Genome Sequence of Streptomyces sp. Strain AM-2504, Identified by 16S rRNA Comparative Analysis as a Streptomyces kasugaensis Strain
Napolioni, V; Cimarelli, L; Miano, A; La Teana, A; Capuni, R; Giuliodori, AM; Fabbretti, A; Spurio, R.
Microbiology resource announcements. Volume / Issue / Pages:8(38):-. DOi: 10. 1128/MRA. 00966-19
Editorial Activity
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Joaquín Castilla
Advisory Board
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Óscar Millet
Associate Editor
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Juan Anguita
Editor Board
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Óscar Millet
Editor Board
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Juan Anguita
Editor Board
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Francisco Blanco
Editor Board
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Antonio Del Sol
Editor Board
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Óscar Millet
Associate Editor
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Óscar Millet
Editor Board
Jesús Jiménez Barbero
Advisory Board
Jesús Jiménez Barbero
Advisory Board
Jesús Jiménez Barbero
Advisory Board
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Félix Elortza
Associate Editor
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Juan M. Falcón
Review Editor
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Rosa Barrio
Review Editor
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Juan Anguita
Review Editor
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Juan Anguita
Review Editor
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Jesús Jiménez Barbero
Associate Editor
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Jesús Jiménez Barbero
Advisory Board
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Juan Anguita
Editor Board
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Juan Anguita
Editor Board
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Rosa Barrio
Editor Board
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Óscar Millet
Associate Editor
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Félix Elortza
Associate Editor
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María Vivanco
Editor Board
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Jesús Jiménez Barbero
Advisory Board
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Jesús Jiménez Barbero
Advisory Board
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Jesús Jiménez Barbero
Advisory Board
Jesús Jiménez Barbero
Advisory Board
Óscar Millet
Editor Board
Joaquín Castilla
Editor Board
Joaquín Castilla
Editor Board
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Francisco Blanco
Editor Board
ERC
0 M€
1 Advanced Grant
- ERC-2017-AdG: RECGLYCANMR - Breaking the limits in glycan recognition by NMR (Jesús Jiménez Barbero)
1 Consolidator Grant
- ERC-2018-CoG: CancerADAPT - Targeting the adaptative capacity of prostate cancer through the manipulation of transcriptional and metabolic traits (Arkaitz Carracedo)
3 Starting Grants
- ERC-2013-StG: CANCERMETAB - Metabolic requirements for prostate cancer cell fitness (Arkaitz Carracedo)
- ERC-2016-StG: ADJUV-ANT VACCINES - Elucidating the Molecular Mechanisms of Synthetic Saponin Adjuvants and Development of Novel Self-Adjuvanting Vaccines (Alberto Fernández-Tejada)
- ERC-2017-StG: NextGen IO - Exploiting the hypoxia response in T cells for NextGeneration Immuno-Oncology (Asís Palazón)
1 Proof of Concept Grant
- ERC-2016-PoC: MetaboMARKER - A metabolism bases prognostic biomarker for prostate cancer (Arkaitz Carracedo)
New Projects
Asís Palazón
ERC Starting Grant
NextGen IO: Exploiting the hypoxia response in T cells for NextGeneration Immuno-Oncology Espacio extra para maquetación html
0 €
Arkaitz Carracedo
ERC Consolidator Grant
CancerADAPT: Targeting the adaptative capacity of prostate cancer through the manipulation of transcriptional and metabolic traits
0 €
Special Projects
MSCA Innovative Training Networks ETN
Anti-bacterial Innovative Vaccine Training Network - BactiVax Espacio extra para maquetación html
Coordinator
University College Dublin
Partner Organization
Atlas Molecular Pharma
0 €
Gilead Sciences International Research Scholars Program 2019
Metabolic adaptation as an essential requirement for live generation
0 €
MSCA Innovative Training Networks ETN
The life cycle of extracellular vesicles in prostate cancer: from biogenesis and homing, to funcional relevance - ProEVLifeCycle
Coordinator
Erasmus University Medical Center (Netherlands)
0 €
Ayuda a Equipos de Investigación Científica
Glutamine Metabolism in the Brain Liver axis in NAFLD-UMBRELLA
0 €
Rare Diseases
For improving diagnostics and Grasping the disease mechanisms of rare Hypomagnesemia in patients with CNNM2 mutations - FIGHT - CNNM2
Coordinator
Netherlands
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Asociación de pacientes |
0 €
XVI Beca Fero Investigación Oncológica Traslacional
Targeting the immune epigenome for next generation Immuno-oncology
0 €
HR Funding
Ikerbasque Research Fellow
June Ereño
Ikerbasque Research Fellow
Marco Piva
"La Caixa" Doctoral Fellowship INPHINIT - Incoming at Research Centers of Excellence
Early Stage Researcher:
Gabriel Soares Guerra
0 €
"La Caixa" Doctoral Fellowship INPHINIT - Retaining at Research Centers of Excellence
Early Stage Researcher:
Mikel García Alija
0 €
Postdoctoral AECC 2019
Postdoctoral researcher:
Laura Bozal Basterra
0 + 0 €
Investigator: Beatriz Trastoy
IP: Marcelo Guerín
MSCA Individual Fellowship
Glyco Mabs: Chemoenzymatic glycoengineering of therapeutic monoclonal antibodies
0 €
Recognitions
XIV Premio Fundación Banco Sabadell a la Investigación Biomédica
0 €
Antonio Del Sol Mesa receives the National Research Funds Award (Luxembourg) for his article published in Nature Communications
The Royal Spanish Society of Chemistry and Elsevier reward the young researcher Iñaki Bastida Saiz
L’Oréal-Unesco For Women in Science 2019 awards Verónica Torrano
Scientific Programmes
- Personalized medicine
- Prostate Cancer
- Breast Cancer
- Colorectal Cancer
- Liver Diseases
- Rare Diseases
- Biomarkers for Diagnosis
- Biomarkers for Prognosis
- Drug Design and Discovery
Molecular Recognition and Host-Pathogen
- Rare Diseases
- Homeostasis
- Viral Infections
- Bacterial Infections
- Prion Disease
- Tick-Borne Disease
- Immune Response
- Drug Design and Discovery
Platforms
- NMR Spectroscopy
- Macromolecular Crystallography
- Electron Microscopy
- Genome Analysis
- Proteomics
- Metabolomics
- Animal Facility
Metabolism and Cell Signaling in Disease
- Personalized medicine
- Prostate Cancer
- Breast Cancer
- Colorectal Cancer
- Liver Diseases
- Rare Diseases
- Biomarkers for Diagnosis
- Biomarkers for Prognosis
- Drug Design and Discovery
Molecular Recognition and Host-Pathogen
- Rare Diseases
- Homeostasis
- Viral Infections
- Bacterial Infections
- Prion Disease
- Tick-Borne Disease
- Immune Response
- Drug Design and Discovery
Technological Platforms
- NMR Spectroscopy
- Macromolecular Crystallography
- Electron Microscopy
- Genome Analysis
- Proteomics
- Metabolomics
- Animal Facility
Generation of
knowledge
Technology
transfer
Commercialization of
results
Scientific Programmes
Research lines
Cancer
Infectious diseases
Rare diseases
The cutting-edge scientific activity of CIC bioGUNE researchers explores the interface between Chemistry and Biomedicine, with emphasis on Structural, Molecular and Cell Biology. An integrative Bioinformatic Program extrapolate relevant conclusion from basic science.
Scientific Programmes
Metabolism & Cell Signaling in Disease
Brain
Breast
Colon
Liver
Prostate
- Target discovery and evaluation of their therapeutic potential
- Cancer and more: Identification of biomarkers with potential diagnostic value
- Novel therapies against rare diseases
- The molecular basis of fibrosis
- Nonalcoholic steatohepatitis
The Research Programmes
Molecular Recognition & Host-Pathogen Interactions
Parasites
Vaccines
Antibiotics
Membrane remodelling
Animal and plant viruses
- Bacterial and Viral Infections: Vaccines for human and animal health
- Mechanisms of membrane remodelling during microbial invasion and propagation
- Plant vaccines and transgenics
- Antibiotics research and molecular characterization
The Research Programmes
Technology Platforms
Genome Analysis Platform
Proteomics Platform
Metabolomics Platform
Animal Facility
Antibodies Production
Drug Repositioning & Discovery
Nuclear Magnetic Resonance
Macromolecular Crystallography
Electron Microscopy Platform
Collaboration Models
Services
R&D Collaborations
Consulting
Theses
0 in progress
Collaboration RVCTI
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0 RVCTI
The PhD Training Program @ CIC bioGUNE
Academic Regulations
- Thesis Advisory Committee (TAC)
- Personal Development Plan
- Annual TAC Meetings and Reports
Advanced Training
- Introductory Week
- Courses
- Seminars
Annual TAC Meetings
| Annex II | Annex III | Annex IV |
| 1st TAC | 2nd TAC | 3rd TAC |
| Well defined thesis project including risk assessment | Monitoring adequate progress in view of the PhD project | Timing of thesis submission |
| Predoc well acquainted with the scientific landscape in which the thesis project is embedded | Refined path forward for following period | What experiments still need to be done to finish up |
| Paperwork ready for University registration | Plan/schedule for publication | Preparation for Thesis Defence |
| Individual development plan | Report/outlook on conference attendance | |
| Individual development plan |
International visits
Prof. Stephen G Withers
The University of British Columbia
Department of Chemistry
Vancouver, Canada
Prof. Robert J Woods
University of Georgia
Complex Carbohydrate Research Center
USA
Visit November 15th
Visit November 28th
Chamber of Commerce and Industry of the Republic of Tatarstan - Nikolaev Artur
Scientific production and Technology Transfer
InnoBerrIkasi
BioBridge
The program provides PhD and MBA students a vehicle toward entrepreneurship through learn-by-doing methodology, at the intersection of Life Sciences, Engineering and Business.
Tech Transfer Seminar
TechBoost
We continuously screen for technologies with high exploitation values for society and scientists are immersed in the development and evaluation of the idea and the generation of models to allow commercialization.
Activities
Activities
Conferences/ Symposiums
Activities
Courses/Workshops/Meetings
High Quality Training
CIC bioGUNE and CIC biomaGUNE collaborate with Deusto University
NEW DEGREE IN MEDICINE
Cooperation and Integration
The Basque Ecosystem. Biosciences/Health
Approach Civil Society
Collaboration Agreements
Enhance External Visibility
Social Media
@CICbioGUNE
CIC bioGUNE Bilbao
CIC bioGUNE
CIC bioGUNE
Create an Alumni Network
In collaboration with Bizkaia Talent:
The talent attraction /retention arm of Basque Country
Dissemination & Outreach
Dissemination and Outreach
Press clippings
Dissemination and Outreach
We have also participated in...
Dissemination and Outreach
YouTube Channel
Dissemination & Outreach
Radio
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Dissemination & Outreach
TV
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