Activity Report 2021
Activity Report 2021
Scientific Programmes
Scientific Programmes
Research lines
Cancer
Infectious diseases
Rare diseases
The cutting-edge scientific activity of CIC bioGUNE researchers explores the interface between Chemistry and Biomedicine, with emphasis on Structural, Molecular and Cell Biology. An integrative Bioinformatics Program extrapolates relevant conclusions from basic science.
- Personalized medicine
- Prostate Cancer
- Breast Cancer
- Colorectal Cancer
- Liver Diseases
- Rare Diseases
- Biomarkers for Diagnosis
- Biomarkers for Prognosis
- Drug Design and Discovery
Molecular Recognition and Host-Pathogen
- Rare Diseases
- Homeostasis
- Viral Infections
- Bacterial Infections
- Prion Disease
- Tick-Borne Disease
- Immune Response
- Drug Design and Discovery
Platforms
- NMR Spectroscopy
- Macromolecular Crystallography
- Electron Microscopy
- Genome Analysis
- Proteomics
- Metabolomics
- Animal Facility
Generation of
knowledge
Technology
transfer
Commercialization of
results
Scientific Programmes
Metabolism & Cell Signaling in Disease
Brain
Breast
Colon
Liver
Prostate
- Target discovery and evaluation of their therapeutic potential
- Cancer and more: Identification of biomarkers with potential diagnostic value
- Novel therapies against rare diseases
- The molecular basis of fibrosis
- Nonalcoholic steatohepatitis
The Research Programmes
Molecular Recognition & Host-Pathogen Interactions
Parasites
Vaccines
Antibiotics
Membrane remodelling
Animal and plant viruses
- Bacterial and Viral Infections: Vaccines for human and animal health
- Mechanisms of membrane remodelling during microbial invasion and propagation
- Plant vaccines and transgenics
- Antibiotics research and molecular characterization
The Research Programmes
Technology Platforms
Genome Analysis Platform
Proteomics Platform
Metabolomics Platform
Animal Facility
Antibodies Production
Drug Repositioning & Discovery
Nuclear Magnetic Resonance
Macromolecular Crystallography
Electron Microscopy Platform
Collaboration Models
Services
R&D Collaborations
Consulting
About Us
Mission:
Conducting research of excellence in the field of the life sciences, covering the entire value of R&D&i, including technology transfer and commercial exploitation of the generated scientific results.
Strategic Challenges:
- Research of excellence
- Technology Transfer
- Collaboration with RVCTI agents
- International recognition
- Training and promotion of research talent
- Attraction and retention of talent
- Communication and Outreach
- Excellence in Management
Strategy:
Commitment to specialization and excellence
Competitiveness:
- Leading infrastructures
- Human Resources
- Technical and administrative support
- Competitive salaries
- Goal-Fulfillment Incentives
Staff
Staff 2021.12.31: 0
FTE (2021): 0
Permanent Staff (FTE): 0 (43,4%)
Gender distribution
-
0% Female
120 -
0% Male
92 -
LISMI - Law of Social Integration of the Handicapped
3
212 Total CIC bioGUNE Personnel
-
0% Research
175 -
0% Administration and Services
37
Researchers Distribution by Professional Category
| nº | % |  |
 |
||
| Researchers | 129 | 73.7 | 62 | 67 | |
| • Principal investigators/Platform Managers | 26 | 14.9 | 7 | 19 | |
| • Postdoctoral Researchers/Research Assistant/Specialist | 47 | 26.9 | 26 | 21 | |
| • PhD Students | 56 | 32.0 | 29 | 27 | |
| Technicians | 46 | 26.3 | 34 | 12 |
Research Distribution by Geographic Origin
Research Distribution by Geographic Origin
-
0% Spain
176 researchers -
0% Rest of Europe
24 researchers -
0% America
10 researchers -
0% Asia
2 researchers
Funding
Total 2021 R&D Budget: 0 million €
Running R&D Projects: 0
New R&D Projects: 0
Public funding
Private funding
-
0 % Competitive Public Funding
14.495 K€ -
0 % Non competitive Public Funding (Emaitek)
6.453 K€
-
0 % Basque Government Departments
9.169 K€ -
0 % R&D Contracts, Research Services & Others
6.636 K€ -
0 % MINECO & MEDC (Spanish Government)
2.950 K€ -
0 % EU & International Projects
2.193 K€
Competitive Incomes (History)
Technology Transfer and Innovation
Economic Activity: 5.705.727€
- Basque Country: 0%
- National: 0%
- International: 0%
New Research Contracts 0
0 Patents Filed
0 Trade Secrets Registered
0 Licensing Agreement
Intellectual Property 2021
Social Commitment
Talent Opportunity
CIC bioGUNE Iniciative
Fellowships programme by Fundación ONCE - CIC bioGUNE - Ikerbasque
- Predoctoral Trainee
- Postdoctoral Trainee
- Postdoctoral Research Fellow
|
|
|||||||||||||||||||||||||||||||||||||||||||
Predoctoral 1 |
Triennial call |
|||||||||||||||||||||||||||||||||||||||||||
Predoctoral 2 |
||||||||||||||||||||||||||||||||||||||||||||
Postdoctoral Trainee 1 |
Triennial call |
|||||||||||||||||||||||||||||||||||||||||||
Postdoctoral Trainee 2 |
||||||||||||||||||||||||||||||||||||||||||||
Postdoctoral Researcher 1 |
Five-year call |
|||||||||||||||||||||||||||||||||||||||||||
Postdoctoral Researcher 2 |
||||||||||||||||||||||||||||||||||||||||||||
General indicators: Equality Plan
Click on the images to see them enlarged in pdf
Equality Plan
Activities
Collaborators
Equality commission:
25N Challenge
- Micromachismos: ¿Te atreves a saber si estás libre de ellos?
- A mí me violenta: Testimonios
NEBTs
New partner: in process
Due Diligence
CLINIC PHASE 1 (2022)
CLINIC PHASE 2 (2022-2023)
Treatment of Congenital Erythropoietic Porphyria (PEC)
Starting date: 18 september 2020
Focus: Ownership, research, design, consulting, innovation and development, exploitation of technologies applied to the processing and analysis of biological, biochemical, biotechnological and medical data
- (DFB): 22 June 2021
- Activity: 1 October 2021
- Incomes 2021: 95000 €
- Job creation: 1 position (2021) + 1 position (2022)
Control COVID-19
Actions
To prevent
- Mask
- Limited people
- Cleaning
- Lunch: 1 - 2 people
- Interpersonal distance
- Tests
PCR
> 90%
personnel
Antibodies
Human Resources Funding
State
Investigator: Leire Moreno
Mentor: Asís Palazón
Investigator: Antonio Franconetti
Mentor: Jesús Jiménez-Barbero
Investigator: Amaia Ercilla
Mentor: Arkaitz Carracedo
Investigator: Francesca Pecatti
Mentor: Gonzalo Jiménez Osés
Investigator:
Marco Piva
Cancer Cell Signaling & Metabolism Lab
Investigator:
Teresa Cardoso
Liver Disease Lab
Investigator:
Urko M. Marigorta
Integrative Genomics Lab (Group Leader)
European
Investigator:
Pablo Valverde
PI: Jesús Jiménez Barbero
MSCA Global Fellowship
Doctoral candidate:
Klaudia Sobczak
PI: June Ereño Orbea
MSCA-ITN GLYTUNES
Private
Doctoral candidate:
Ander de Blas
PI: Asís Palazón
Investigador Predoctoral AECC
Ikerbasque Research Fellows
Amaia Arruabarrena
Marco Piva
Competitive Funding Projects
European
MSCA ITN
June Ereño
GLYTUNES
Arkaitz Carracedo
PIPgen
Coordinators
Università degli studio di Napoli
Federico II
Instituto de Investigación Biomédica
de Bellvitge (IDIBELL)
EU Joint Programmes
Joaquín Castilla
PROFFlle
Mauro D'Amato
GenMalCarb
Coordinators
Istituto di Ricerche Farmacologiche
Mario Negri
University of
Nottingham
State
Funded projects: 0 projects
Total Grant Amount (3 years): 0 M€
Doctoral Candidates: 0 FPI
Mauro D'Amato, Rosa Barrio, José María Mato, Malu Martínez Chantar, Robert Kypta, Alberto Fernández Tejada, María dM Vivanco, Antonio del Sol, Aitor Hierro
Public Funding - Euskadi
COVID-19 - Fundación BIOEF – EITB Maratoia
Coordinator:
Óscar Millet (CIC bioGUNE)
Coordinator:
Urko M. Marigorta (CIC bioGUNE)
Coordinator:
David Otaegui (Biodonostia)
Grants for research and development projects in Health
Department of Health Basque Government
Coordinator:
Óscar Millet (CIC bioGUNE)
Public Funding - State
Incorporación al Consorcio CIBER Enfermedades Infecciosas
Joaquín Castilla
Ayudas para las Infraestructuras Científicas y Técnicas Singulares (ICTS)
Óscar Millet
Pruebas de Concepto, Proyectos de I+D+i
José M. Mato
Alberto Fernández Tejada
Robert Kypta
Pruebas de Investigación de Medicina Personalizada de Precisión
Urko M. Marigorta
Coordination: Jorge Ferrer
Private Funding
LAB AECC
Health Research 2021
Asís Palazón
Coordination: Sonia Guedan (IDIBAPS)
Von Hippel-Lindau Disease
Edurne Berra
Postdoctoral Talent Programme
Isabel Mendizabal
R&D Pilot Project Awards
Coordination: Nicola GA Abrescia
(CIC bioGUNE)
Research Grants
Coordination: Urko M. Marigorta
(CIC bioGUNE)
GETECCU - MSD
Héctor Rodríguez
Edurne Berra
Arkaitz Carracedo
Ayudas a la Investigación 2021 Biomedicina y Salud
Competitive Funding Tech Transfer Projects
Malu Martínez Chantar
Desarrollo Tecnológico en Salud 2020
Mch20: Detecting liver damage through urine
Collaborations
STATE
INNOVATION with Technological Centers Hospitals
Asís Palazón
Desarrollo Tecnológico en Salud 2021
Development of precision serology assays for the post-pandemic era.
Collaboration
Technology Transfer Projects
Basque Funding
Asís Palazón
Cancer Cell Therapy (CAR-T)
NewBornScreening
Óscar Millet
José M. Mato
Newborn Diagnosis for Congenital Diseases
Click on the image to see it enlarged in pdf
Beta tester
Applications
Funding Entity |
January |
February |
March |
April |
May |
June |
July |
August |
September |
October |
November |
December |
Grand Total |
Public National |
12 |
1 |
3 |
5 |
1 |
3 |
3 |
7 |
12 |
47 |
|||
Private National |
2 |
15 |
2 |
1 |
2 |
3 |
2 |
3 |
8 |
5 |
4 | 47 |
|
Public Euskadi |
7 |
6 |
3 |
8 |
1 |
25 |
|||||||
Public Europe |
1 |
3 |
1 |
1 |
1 |
11 |
6 |
24 |
|||||
Private International |
2 |
2 |
5 |
1 |
1 |
1 |
3 |
4 |
1 |
20 |
|||
Private Euskadi |
7 |
7 |
|||||||||||
Private Europe |
1 |
2 |
2 |
5 |
|||||||||
|
16 |
25 |
16 |
8 |
9 |
11 |
8 |
3 |
19 |
26 |
18 |
16 |
175 |
Click on the image to see it enlarged in pdf
Accreditations
Programa Centros Fundación Científica AECC
First Follow-up
December 10, 2021
Click on the image to see it enlarged in pdf
UNE166002 R&D Management
Renewal
December 9 & 10, 2021
Click on the image to see it enlarged in pdf
ELKARTEK 2021
Basque Funding
Coordinator: CIC bioGUNE
Coordinator: Óscar Millet
Institutional Clinical Collaboration
Mix Laboratory for Translational Research in Prostate
Promoted by Arkaitz Carracedo
5-year Impact Factor*: 7.915
Q1
PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer
Amaia Zabala-Letona 1,2 Amaia Arruabarrena-Aristorena 1,3,4 Sonia Fernandez-Ruiz 1,2 Cristina Viera 1,3 Onintza Carlevaris 1, Amaia Ercilla 1,2 Isabel Mendizabal 1,3,4 Teresa Martin 1 Alice Macchia 1,5,4 Laura Camacho 1,5 Mikel Pujana-Vaquerizo 1, Pilar Sanchez-Mosquera 1 Verónica Torrano 1,2,5 Natalia Martin-Martin 1,2,4 Patricia Zuniga-Garcia 1 Mireia Castillo-Martin 6, Aitziber Ugalde-Olano 2,7,6 Ana Loizaga-Iriarte 2,4,8 Miguel Unda 2,4,8 Jose M. Mato 1,9 Edurne Berra 1,2 María L. Martinez-Chantar 1,9,7 Arkaitz Carracedo 1,2,3,4,5,10
4Traslational prostate cancer Research lab, CIC bioGUNE-Basurto, Biocruces Bizkaia Health Research Institute
Objetives:
- Foster corporate collaboration with Hospitals
- Foster translational R&D to Hospitals (preclinical and clinical)
- Provide Offers for Joint services
- Armonize bi-directional flow of ideas from bench to bedside
Technology Transfer and Innovation
8 Invention Disclosures (IDF) filed by CIC bioGUNE investigators
Intellectual Property
Patent List (5 European priority filing)
- Methods for the generation of stem cell memory T cells for adoptive T cell therapy
- miRNA signature for identification of the receptive endometrium
- Saponin-based adjuvants and vaccines
- new formulation for ciclopirox
- Self/adjuvanting saponins
Industrial secrets (4 registered)
Business Leads generation
- 0 New business leads
- 0 New MTA
- 0 New CDA signed with companies
- 0 Sponsorship Agreements
- 0 Licensing Options
- 0 Licensing Agreement
- 0 Ongoing Industrial Doctorates
Publications
12
Average Impact Factor
40% Collaboration RVCTI
 |
 |
 |
 |
 |
 |
|
 |
 |
 |
 |
 |
Scientific Highlights
Microscopic colitis
Burke KE, D'Amato M, Ng SC, Pardi DS, Ludvigsson JF, Khalili H
. Nat Rev Dis Primers. 2021 Jun 10;7(1):39. doi: 10.1038/s41572-021-00273-2
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
Eijsbouts C, Zheng T, Kennedy NA, Bonfiglio F, Anderson CA, Moutsianas L, Holliday J, Shi J, Shringarpure S; 23andMe Research Team, Voda AI; Bellygenes Initiative, Farrugia G, Franke A, Hübenthal M, Abecasis G, Zawistowski M, Skogholt AH, Ness-Jensen E, Hveem K, Esko T, Teder-Laving M, Zhernakova A, Camilleri M, Boeckxstaens G, Whorwell PJ, Spiller R, McVean G, D'Amato M, Jostins L, Parkes M
Nat Genet. 2021 Nov;53(11):1543-1552. doi: 10.1038/s41588-021-00950-8
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Võsa U, Claringbould A, Westra HJ, Bonder MJ, Deelen P, Zeng B, Kirsten H, Saha A, Kreuzhuber R, Yazar S, Brugge H, Oelen R, de Vries DH, van der Wijst MGP, Kasela S, Pervjakova N, Alves I, Favé MJ, Agbessi M, Christiansen MW, Jansen R, Seppälä I, Tong L, Teumer A, Schramm K, Hemani G, Verlouw J, Yaghootkar H, Sönmez Flitman R, Brown A, Kukushkina V, Kalnapenkis A, Rüeger S, Porcu E, Kronberg J, Kettunen J, Lee B, Zhang F, Qi T, Hernandez JA, Arindrarto W, Beutner F; BIOS Consortium; i2QTL Consortium, Dmitrieva J, Elansary M, Fairfax BP, Georges M, Heijmans BT, Hewitt AW, Kähönen M, Kim Y, Knight JC, Kovacs P, Krohn K, Li S, Loeffler M, Marigorta UM, Mei H, Momozawa Y, Müller- Nurasyid M, Nauck M, Nivard MG, Penninx BWJH, Pritchard JK, Raitakari OT, Rotzschke O, Slagboom EP, Stehouwer CDA, Stumvoll M, Sullivan P, 't Hoen PAC, Thiery J, Tönjes A, van Dongen J, van Iterson M, Veldink JH, Völker U, Warmerdam R, Wijmenga C, Swertz M, Andiappan A, Montgomery GW, Ripatti S, Perola M, Kutalik Z, Dermitzakis E, Bergmann S, Frayling T, van Meurs J, Prokisch H, Ahsan H, Pierce BL, Lehtimäki T, Boomsma DI, Psaty BM, Gharib SA, Awadalla P, Milani L, Ouwehand WH, Downes K, Stegle O, Battle A, Visscher PM, Yang J, Scholz M, Powell J, Gibson G, Esko T, Franke L
Nat Genet. 2021 Sep;53(9):1300-1310. doi: 10.1038/s41588-021-00913-z
Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy
Wang Y, Liu S, Yang Z, Algazi AP, Lomeli SH, Wang Y, Othus M, Hong A, Wang X, Randolph CE, Jones AM, Bosenberg MW, Byrum SD, Tackett AJ, Lopez H, Yates C, Solit DB, Ribas A, Piva M, Moriceau G, Lo RS
Cancer Cell. 2021 Oct 11;39(10):1375-1387.e6. doi: 10.1016/j.ccell.2021.07.023
Systemic Inflammation in Preclinical Ulcerative Colitis
Bergemalm D, Andersson E, Hultdin J, Eriksson C, Rush ST, Kalla R, Adams AT, Keita Ã…V, D'Amato M, Gomollon F, Jahnsen J; IBD Character Consortium, Ricanek P, Satsangi J, Repsilber D, Karling P, Halfvarson J
Gastroenterology. 2021 Nov;161(5):1526-1539.e9. doi: 10.1053/j.gastro.2021.07.026
Multi-Omics Analyses Show Disease, Diet, and Transcriptome Interactions With the Virome
Mihindukulasuriya KA, Mars RAT, Johnson AJ, Ward T, Priya S, Lekatz HR, Kalari KR, Droit L, Zheng T, Blekhman R, D'Amato M, Farrugia G, Knights D, Handley SA, Kashyap PC
Gastroenterology. 2021 Oct;161(4):1194-1207.e8. doi: 10.1053/j.gastro.2021.06.077
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease
Zheng T, Ellinghaus D, Juzenas S, Cossais F, Burmeister G, Mayr G, Jørgensen IF, Teder-Laving M, Skogholt AH, Chen S, Strege PR, Ito G, Banasik K, Becker T, Bokelmann F, Brunak S, Buch S, Clausnitzer H, Datz C; DBDS Consortium, Degenhardt F, Doniec M, Erikstrup C, Esko T, Forster M, Frey N, Fritsche LG, Gabrielsen ME, Gräßle T, Gsur A, Gross J, Hampe J, Hendricks A, Hinz S, Hveem K, Jongen J, Junker R, Karlsen TH, Hemmrich-Stanisak G, Kruis W, Kupcinskas J, Laubert T, Rosenstiel PC, Röcken C, Laudes M, Leendertz FH, Lieb W, Limperger V, Margetis N, Mätz-Rensing K, Németh CG, Ness-Jensen E, Nowak-Göttl U, Pandit A, Pedersen OB, Peleikis HG, Peuker K, Rodriguez CL, Rühlemann MC, Schniewind B, Schulzky M, Skieceviciene J, Tepel J, Thomas L, Uellendahl-Werth F, Ullum H, Vogel I, Volzke H, von Fersen L, von Schönfels W, Vanderwerff B, Wilking J, Wittig M, Zeissig S, Zobel M, Zawistowski M, Vacic V, Sazonova O, Noblin ES; 23andMe Research Team, Farrugia G, Beyder A, Wedel T, Kahlke V, Schafmayer C, D'Amato M, Franke A
Gut. 2021 Apr 22;70(8):1538–49. doi: 10.1136/gutjnl-2020-323868
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms
Esparza-Baquer A, Labiano I, Sharif O, Agirre-Lizaso A, Oakley F, Rodrigues PM, Zhuravleva E, O'Rourke CJ, Hijona E, Jimenez-Agüero R, Riaño I, Landa A, La Casta A, Zaki MYW, Munoz-Garrido P, Azkargorta M, Elortza F, Vogel A, Schabbauer G, Aspichueta P, Andersen JB, Knapp S, Mann DA, Bujanda L, Banales JM, Perugorria MJ
Gut. 2021 Jul;70(7):1345-1361. doi: 10.1136/gutjnl-2019-319227
Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells
Nolan LM, Cain AK, Clamens T, Furniss RCD, Manoli E, Sainz-Polo MA, Dougan G, Albesa-Jové D, Parkhill J, Mavridou DAI, Filloux A
Nat Microbiol. 2021 Sep;6(9):1199-1210. doi: 10.1038/s41564-021-00950-8
Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH
Simón J, Goikoetxea-Usandizaga N, Serrano-Maciá M, Fernández-Ramos D, Sáenz de Urturi D, Gruskos JJ, Fernández-Tussy P, Lachiondo-Ortega S, González-Recio I, Rodríguez-Agudo R, Gutiérrez-de-Juan V, Rodríguez-Iruretagoyena B, Varela-Rey M, Gimenez-Mascarell P, Mercado-Gomez M, Gómez-Santos B, Fernandez-Rodriguez C, Lopitz-Otsoa F, Bizkarguenaga M, Dames S, Schaeper U, Martin F, Sabio G, Iruzubieta P, Crespo J, Aspichueta P, Chu KH, Buccella D, Martín C, Delgado TC, Martínez-Cruz LA, Martínez-Chantar ML
J Hepatol. 2021 Jul;75(1):34-45. doi: 10.1016/j.jhep.2021.01.043
Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
Fernandez-Checa JC, Bagnaninchi P, Ye H, Sancho-Bru P, Falcon-Perez JM, Royo F, Garcia-Ruiz C, Konu O, Miranda J, Lunov O, Dejneka A, Elfick A, McDonald A, Sullivan GJ, Aithal GP, Lucena MI, Andrade RJ, Fromenty B, Kranendonk M, Cubero FJ, Nelson LJ
J Hepatol. 2021 Oct;75(4):935-959. doi: 10.1016/j.jhep.2021.06.021
Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models
Lee-Law PY, Olaizola P, Caballero-Camino FJ, Izquierdo-Sanchez L, Rodrigues PM, Santos-Laso A, Azkargorta M, Elortza F, Martinez-Chantar ML, Perugorria MJ, Aspichueta P, Marzioni M, LaRusso NF, Bujanda L, Drenth JPH, Banales JM
J Hepatol. 2021 Feb;74(2):394-406. doi: 10.1016/j.jhep.2020.09.010
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold
Basler S, Studer S, Zou Y, Mori T, Ota Y, Camus A, Bunzel HA, Helgeson RC, Houk KN, Jiménez-Osés G, Hilvert D
Nat Chem. 2021 Mar;13(3):231-235. doi: 10.1038/s41557-020-00628-4 Â
The Importance of Computational Modeling in Stem Cell Research
Del Sol A, Jung S
Trends Biotechnol. 2021 Feb;39(2):126-136. doi: 10.1016/j.tibtech.2020.07.006
Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate
Prieto-Fernández E, Egia-Mendikute L, Vila-Vecilla L, Bosch A, Barreira- Manrique A, Lee SY, García-Del Río A, Antoñana-Vildosola A, Jiménez-Lasheras B, Moreno-Cugnon L, Jiménez-Barbero J, Berra E, Ereño-Orbea J, Palazon A
Emerg Microbes Infect. 2021 Dec;10(1):1065-1076. doi: 10.1080/22221751.2021.1932607
Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding
Han S, Okawa S, Wilkinson GA, Ghazale H, Adnani L, Dixit R, Tavares L, Faisal I, Brooks MJ, Cortay V, Zinyk D, Sivitilli A, Li S, Malik F, Ilnytskyy Y, Angarica VE, Gao J, Chinchalongporn V, Oproescu AM, Vasan L, Touahri Y, David LA, Raharjo E, Kim JW, Wu W, Rahmani W, Chan JA, Kovalchuk I, Attisano L, Kurrasch D, Dehay C, Swaroop A, Castro DS, Biernaskie J, Del Sol A, Schuurmans C
Neuron. 2021 Sep 15;109(18):2847-2863.e11. doi: 10.1016/j.neuron.2021.07.007
Preventing Memory Effects in Surface-Enhanced Raman Scattering Substrates by Polymer Coating and Laser-Activated Deprotection
Plou J, Charconnet M, García I, Calvo J, Liz-Marzán LM
ACS Nano. 2021 May 25;15(5):8984-8995. doi: 10.1021/acsnano.1c01878
Identification of proximal SUMO- dependent interactors using SUMO-ID
Barroso-Gomila O, Trulsson F, Muratore V, Canosa I, Merino-Cacho L, Cortazar AR, Pérez C, Azkargorta M, Iloro I, Carracedo A, Aransay AM, Elortza F, Mayor U, Vertegaal ACO, Barrio R, Sutherland JD
Nat Commun. 2021 Nov 18;12(1):6671. doi: 10.1038/s41467-021-26807-6
O-GlcNAcylated p53 in the liver modulates hepatic glucose production
Gonzalez-Rellan MJ, Fondevila MF, Fernandez U, Rodríguez A, Varela-Rey M, Veyrat-Durebex C, Seoane S, Bernardo G, Lopitz-Otsoa F, Fernández-Ramos D, Bilbao J, Iglesias C, Novoa E, Ameneiro C, Senra A, Beiroa D, Cuñarro J, Dp Chantada-Vazquez M, Garcia-Vence M, Bravo SB, Da Silva Lima N, Porteiro B, Carneiro C, Vidal A, Tovar S, Müller TD, Ferno J, Guallar D, Fidalgo M, Sabio G, Herzig S, Yang WH, Cho JW, Martinez-Chantar ML, Perez-Fernandez R, López M, Dieguez C, Mato JM, Millet O, Coppari R, Woodhoo A, Fruhbeck G, Nogueiras R
Nat Commun. 2021 Aug 20;12(1):5068. doi: 10.1038/s41467-021-25390-0
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion
Gonçalves CA, Larsen M, Jung S, Stratmann J, Nakamura A, Leuschner M, Hersemann L, Keshara R, Perlman S, Lundvall L, Thuesen LL, Hare KJ, Amit I, Jørgensen A, Kim YH, Del Sol A, Grapin-Botton A
. Nat Commun. 2021 May 25;12(1):3144. doi: 10.1038/s41467-021-23295-6
Evolution of DNA methylation in the human brain
Jeong H, Mendizabal I, Berto S, Chatterjee P, Layman T, Usui N, Toriumi K, Douglas C, Singh D, Huh I, Preuss TM, Konopka G, Yi SV
Nat Commun. 2021 Apr 1;12(1):2021. doi: 10.1038/s41467-021-21917-7
A computer-guided design tool to increase the efficiency of cellular conversions
Jung S, Appleton E, Ali M, Church GM, Del Sol A
Nat Commun. 2021 Mar 12;12(1):1659. doi: 10.1038/s41467-021-21801-4
Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer
Shephard AP, Giles P, Mbengue M, Alraies A, Spary LK, Kynaston H, Gurney MJ, Falcón-Pérez JM, Royo F, Tabi Z, Parthimos D, Errington RJ, Clayton A, Webber JP
J Extracell Vesicles. 2021 Oct;10(12):e12150. doi: 10.1002/jev2.12150
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles
Erdbrügger U, Blijdorp CJ, Bijnsdorp IV, Borrà s FE, Burger D, Bussolati B, Byrd JB, Clayton A, Dear JW, Falcón-Pérez JM, Grange C, Hill AF, Holthöfer H, Hoorn EJ, Jenster G, Jimenez CR, Junker K, Klein J, Knepper MA, Koritzinsky EH, Luther JM, Lenassi M, Leivo J, Mertens I, Musante L, Oeyen E, Puhka M, van Royen ME, Sánchez C, Soekmadji C, Thongboonkerd V, van Steijn V, Verhaegh G, Webber JP, Witwer K, Yuen PST, Zheng L, Llorente A, Martens-Uzunova ES
J Extracell Vesicles. 2021 May;10(7):e12093. doi: 10.1002/jev2.12093
S-adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells
Ramani K, Robinson AE, Berlind J, Fan W, Abeynayake A, Binek A, Barbier- Torres L, Noureddin M, Nissen NN, Yildirim Z, Erbay E, Mato JM, Van Eyk JE, Lu SC
Hepatology. 2022 Feb;75(2):280-296. doi: 10.1002/hep.32130
Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals
Goikoetxea-Usandizaga N, Serrano-Maciá M, Delgado TC, Simón J, Fernández Ramos D, Barriales D, Cornide ME, Jiménez M, Pérez-Redondo M, Lachiondo-Ortega S, Rodríguez-Agudo R, Bizkarguenaga M, Zalamea JD, Pasco ST, Caballero-Díaz D, Alfano B, Bravo M, González-Recio I, Mercado-Gómez M, Gil-Pitarch C, Mabe J, Gracia-Sancho J, Abecia L, Lorenzo Ó, Martín-Sanz P, Abrescia NGA, Sabio G, Rincón M, Anguita J, Miñambres E, Martín C, Berenguer M, Fabregat I, Casado M, Peralta C, Varela-Rey M, Martínez-Chantar ML
Hepatology. 2022 Mar;75(3):550-566. doi: 10.1002/hep.32149
Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of Experimental Cholangiocarcinoma
Colyn L, Bárcena-Varela M, Ã�lvarez-Sola G, Latasa MU, Uriarte I, Santamaría E, Herranz JM, Santos-Laso A, Arechederra M, Ruiz de Gauna M, Aspichueta P, Canale M, Casadei-Gardini A, Francesconi M, Carotti S, Morini S, Nelson LJ, Iraburu MJ, Chen C, Sangro B, Marin JJG, Martinez-Chantar ML, Banales JM, Arnes- Benito R, Huch M, Patino JM, Dar AA, Nosrati M, Oyarzábal J, Prósper F, Urman J, Cubero FJ, Trautwein C, Berasain C, Fernandez-Barrena MG, Avila MA
Hepatology. 2021 Jun;73(6):2380-2396. doi: 10.1002/hep.31642
Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome
Bernardo-Seisdedos G, Bilbao J, Fernández-Ramos D, Lopitz-Otsoa F, Gutierrez de Juan V, Bizkarguenaga M, Mateos B, Fondevila MF, Abril-Fornaguera J, Diercks T, Lu SC, Nogueiras R, Mato JM, Millet O
Hepatology. 2021 Jul;74(1):148-163. doi: 10.1002/hep.31676
Nuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer development
Font-Díaz J, Jiménez-Panizo A, Caelles C, Vivanco MD, Pérez P, Aranda A, Estébanez-Perpiñá E, Castrillo A, Ricote M, Valledor AF
Semin Cancer Biol. 2021 Aug;73:58-75. doi: 10.1016/j.semcancer.2020.12.007
Chemoenzymatic Synthesis of Complex N-Glycans of the Parasite S. mansoni to Examine the Importance of Epitope Presentation on DC-SIGN recognition
Srivastava AD, Unione L, Bunyatov M, Gagarinov IA, Delgado S, Abrescia NGA, Ardá A, Boons GJ
Angew Chem Int Ed Engl. 2021 Aug 23;60(35):19287-19296. doi: 10.1002/anie.202105647
Unambiguous Tracking of Protein Phosphorylation by Fast High-Resolution FOSY NMR*
Lesovoy DM, Georgoulia PS, Diercks T, Mate�ko-Burmann I, Burmann BM, Bocharov EV, Bermel W, Orekhov VY
Angew Chem Int Ed Engl. 2021 Oct 25;60(44):23540-23544. doi: 10.1002/anie.202102758
Selective 13 C-Labels on Repeating Glycan Oligomers to Reveal Protein Binding Epitopes through NMR: Polylactosamine Binding to Galectins
Moure MJ, Gimeno A, Delgado S, Diercks T, Boons GJ, Jiménez-Barbero J, Ardá A
Angew Chem Int Ed Engl. 2021 Aug 16;60(34):18777-18782. doi: 10.1002/anie.202106056
Substrate Sequence Controls Regioselectivity of Lanthionine Formation by ProcM
Le T, Jeanne Dit Fouque K, Santos-Fernandez M, Navo CD, Jiménez-Osés G, Sarksian R, Fernandez-Lima FA, van der Donk WA
J Am Chem Soc. 2021 Nov 10;143(44):18733-18743. doi: 10.1021/jacs.1c09370
Origin and Control of Chemoselectivity in Cytochrome c Catalyzed Carbene Transfer into Si–H and N–H bonds
Garcia-Borrà s M, Kan SBJ, Lewis RD, Tang A, Jimenez-Osés G, Arnold FH, Houk KN
J Am Chem Soc. 2021 May 12;143(18):7114-7123. doi: 10.1021/jacs.1c02146
A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit
Schedlbauer A, Iturrioz I, Ochoa-Lizarralde B, Diercks T, López-Alonso JP, Lavin JL, Kaminishi T, Çapuni R, Dhimole N, de Astigarraga E, Gil-Carton D, Fucini P, Connell SR
Sci Adv. 2021 Jun 4;7(23):eabf7547. doi: 10.1126/sciadv.abf7547
Trimethylamine N-oxide is a new plant molecule that promotes abiotic stress tolerance
Catalá R, López-Cobollo R, Berbís MÃ�, Jiménez-Barbero J, Salinas J.
Sci Adv. 2021 May 19;7(21):eabd9296. doi: 10.1126/sciadv.abd9296
Leveraging systems biology for predicting modulators of inflammation in patients with COVID-19
Jung S, Potapov I, Chillara S, Del Sol A
Sci Adv. 2021 Feb 3;7(6):eabe5735. doi: 10.1126/sciadv.abe5735
FunRes: resolving tissue-specific functional cell states based on a cell-cell communication network model
Jung S, Singh K, Del Sol A
Brief Bioinform. 2021 Jul 20;22(4):bbaa283. doi: 10.1093/bib/bbaa283
An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity
Compte M, Harwood SL, Erce-Llamazares A, Tapia-Galisteo A, Romero E, Ferrer I, Garrido-Martin EM, Enguita AB, Ochoa MC, Blanco B, Oteo M, Merino N, Nehme- Ã�lvarez D, Hangiu O, Domínguez-Alonso C, Zonca M, Ramírez-Fernández A, Blanco FJ, Morcillo MA, Muñoz IG, Melero I, Rodriguez-Peralto JL, Paz-Ares L, Sanz L, Alvarez-Vallina L
Clin Cancer Res. 2021 Jun 1;27(11):3167-3177. doi: 10.1158/1078-0432.CCR-20-4625
pH-Responsive Self-Assembly of Amyloid Fibrils for Dual Hydrolase-Oxidase Reactions
Diaz-Caballero M, Navarro S, Nuez-Martinez M, Peccati F, Rodriguez-Santiago L, Sodupe M, Teixidor F, Ventura S
ACS Catalysis. 2021 Jan 15; 11(2):Â 595-607. doi: 10.1021/acscatal.0c03093
E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment
González-Romero F, Mestre D, Aurrekoetxea I, O'Rourke CJ, Andersen JB, Woodhoo A, Tamayo-Caro M, Varela-Rey M, Palomo-Irigoyen M, Gómez-Santos B, de Urturi DS, Núñez-García M, García-Rodríguez JL, Fernández-Ares L, Buqué X, Iglesias-Ara A, Bernales I, De Juan VG, Delgado TC, Goikoetxea-Usandizaga N, Lee R, Bhanot S, Delgado I, Perugorria MJ, Errazti G, Mosteiro L, Gaztambide S, Martinez de la Piscina I, Iruzubieta P, Crespo J, Banales JM, Martínez-Chantar ML, Castaño L, Zubiaga AM, Aspichueta P
Cancer Res. 2021 Jun 1;81(11):2874-2887. doi: 10.1158/0008-5472.CAN-20-2052
Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating
Harley CA, Bernardo-Seisdedos G, Stevens-Sostre WA, Jones DK, Azevedo MM, Sampaio P, Lorga-Gomes M, Trudeau MC, Millet O, Robertson GA, Morais-Cabral JH
Proc Natl Acad Sci U S A. 2021 Nov 2;118(44):e2108796118. doi: 10.1073/pnas.2108796118
Nanocomposite Scaffolds for Monitoring of Drug Diffusion in Three-Dimensional Cell Environments by Surface-Enhanced Raman Spectroscopy
Plou J, Molina-Martínez B, García-Astrain C, Langer J, García I, Ercilla A, Perumal G, Carracedo A, Liz-Marzán LM
Nano Lett. 2021 Oct 27;21(20):8785-8793. doi: 10.1021/acs.nanolett.1c03070
Reviews
Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests
Masoodi M, Gastaldelli A, Hyötyläinen T, Arretxe E, Alonso C, Gaggini M, Brosnan J, Anstee QM, Millet O, Ortiz P, Mato JM, Dufour JF, Oreši� M
Nat Rev Gastroenterol Hepatol. 2021 Dec;18(12):835-856. doi: 10.1038/s41575-021-00502-9
Advances in chemical probing of protein O-GlcNAc glycosylation: structural role and molecular mechanisms
Saha A, Bello D, Fernández-Tejada A
Chem Soc Rev. 2021 Sep 20;50(18):10451-10485. doi: 10.1039/d0cs01275k
Natural and synthetic carbohydrate- based vaccine adjuvants and their mechanisms of action
Pifferi C, Fuentes R, Fernández-Tejada A
Nat Rev Chem. 2021;5(3):197-216. doi: 10.1038/s41570-020-00244-3
Computational Stem Cell Biology: Open Questions and Guiding Principles
Cahan P, Cacchiarelli D, Dunn SJ, Hemberg M, de Sousa Lopes SMC, Morris SA, Rackham OJL, Del Sol A, Wells CA
Cell Stem Cell. 2021 Jan 7;28(1):20-32. doi: 10.1016/j.stem.2020.12.012
Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions
Franconetti A, Ardá A, Asensio JL, Blériot Y, Thibaudeau S, Jiménez-Barbero J
Acc Chem Res. 2021 Jun 1;54(11):2552-2564. doi: 10.1021/acs.accounts.1c00021
Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles
Bordanaba-Florit G, Royo F, Kruglik SG, Falcón-Pérez JM
Nat Protoc. 2021 Jul;16(7):3163-3185. doi: 10.1038/s41596-021-00551-z
Extracellular vesicles in hepatology: Physiological role, involvement in pathogenesis, and therapeutic opportunities
Azparren-Angulo M, Royo F, Gonzalez E, Liebana M, Brotons B, Berganza J, Goñi-de-Cerio F, Manicardi N, Abad-Jordà L, Gracia-Sancho J, Falcon-Perez JM
Pharmacol Ther. 2021 Feb;218:107683. doi: 10.1016/j.pharmthera.2020.107683
Editorial Activity
-
-
Joaquín Castilla
Advisory BoardJuan Anguita
Editor Board
-
-
Óscar Millet
Associate Editor
-
-
Óscar Millet
Editor Board
-
-
Juan Anguita
Editor Board
-
-
Malu Martínez Chantar
Editor Board
-
-
Óscar Millet
Editor Board
-
-
Rosa Barrio
Editor BoardJuan Anguita
Senior EditorÓscar Millet
Editor Board
-
-
Félix Elortza
Editor Board
-
-
Malu Martínez Chantar
Associate Editor
-
-
Asís Palazón
Associate EditorJuan Anguita
Guest Associate Editor
-
-
Joaquín Castilla
Associate Editor
-
-
Rosa Barrio
Associate Editor
-
-
Rosa Barrio
Editor
-
-
María Vivanco
Editor Board
-
-
Arkaitz Carracedo
Consultant Editor
-
-
Jesús Jiménez-Barbero
Associate Editor
-
-
Jesús Jiménez-Barbero
Advisory Board
-
-
Malu Martínez Chantar
Editor Board
-
-
Antonio Del Sol
Editor BoardÓscar Millet
Editor Board
-
-
Félix Elortza
Editor Board
Edurne Berra
Associate Editor
Juan Manuel Falcón
Deputy Editor
Jesús Jiménez-Barbero
Advisory Board
Jesús Jiménez-Barbero
Advisory Board
Robert Kypta
Editor Board
Jesús Jiménez-Barbero
Editor Board
Óscar Millet
Editor Board
Joaquín Castilla
Editor Board
Joaquín Castilla
Editor Board
Juan Anguita
Editor Board
Training – Doctoral Candidates
The CIC bioGUNE Advanced Training Program
Introductory week: September 27th to October 1st
Theses
0 in progress
Collaboration RVCTI
|
 |
|
|
|
|
|
|
|
 |
|
|
 |
 |
|
0 RVCTI
Thesis
May 28
Rafael López Moreno
Estudio de la diversidad y estabilidad de diferentes priones recombinantes infecciosos para dilucidar los mecanismos moleculares que rigen el fenómeno de cepa
June 8
José Daniel Martínez Ordóñez
Novel ligand-based 19F-NMR and computational approaches for studying sugar-lectin molecular recognition events
June 18
Maria Pia Lenza
Deciphering the recognition features of glycans by human lectins at the molecular level
Sept 17
Miguel Ángel Pérez Castro
Generación de distintas cepas de priones recombinantes como herramienta para el estudio del malplegamiento espontáneo en las enfermedades priónicas
Sept 22
Iraia Laredo Auñón
Vaccine immunomodulation and protection mechanisms against
Nov 26
Lucia Maio
Designed Metallo-Tags for Probing Natural Systems
Dic 1
Cristina Risueño
Modulating the Conformational Plasticity of Tetraspanin CD81 by Ligand Binders and its Implication in Cellular and Viral Processes
Dic 13
Saray Sánchez Yagüe
Antibody-mediated inhibition of Wnt-11 in prostate cancer
Dic 20
Diego Barriales
Plasticity of macrophage responses to activating factors
Degree in Medicine.
University of Deusto
2020-2021 & 2021-2022
M3
Chemistry Applied to Life Sciences
Coordinated by Joaquín Castilla
M4
Homeostasis and regulation
Coordinated by Edurne Berra
2021-2022
M3
M4
M7
Clinical/medical genetics
Coordinated by Ana M Aransay and Urko M Marigorta
New Scientific Advisory Board (SAB)
Recognitions
Ikerbasque y el Departamento de Educación reconocen y visibilizan la labor de las mujeres investigadoras
Dra. Malu Martínez Chantar
Click on the image to see it enlarged in pdf
Best PhD Thesis in NMR
Pablo Valverde
Borja Mateos
Activities
Joint Meeting
Nov 19th
AECC patients
Nov 22th
BactiVax Meeting
Nov 22-25th
Scientific Outreach
Bulletin
Click on the images to see them enlarged in pdf
Scientific Annual Review
Click on the image to see it enlarged in pdf
Highlights
A new Strategic Plan (2022-2025) has been presented to the general Board of CIC bioGUNE in November 2021.
CIC bioGUNE investigators publish more than 200 publications in 2021. More than 30% have been presented in D1 Journals. CIC publications are cited more than 9000 times in 2021.
CIC bioGUNE investigators file 5 EPO and 1 PCT applications.
CIC bioGUNE researchers are awarded with 58 new competitive R+D projects, funded by public and private institutions. 171 R+D projects are running along 2021.
Mauro D'Amato joins CIC bioGUNE as Group Leader of the Gastrointestinal Genetics Lab.
CIC bioGUNE renews the certification as "Agente Científico Tecnológico" of the Basque Network of Science, Technology and Innovation as well as its AAALAC seal for the animal facility.
CIC bioGUNE approves its new Equality Plan.
The Mixed Laboratory for Translational Research in Prostate Cancer is created through the alliance os CIC bioGUNE with OSI Basurto Hospital and Biocruces Bizkaia Health Institute.
ATLAS MOLECULAR PHARMA. S.L., spin-off company of CIC bioGUNE, finishes a round of share capital increase above 3 M€, to enter into the Clinical Phases I & II of its drug to treat Congenital Erythropoietic Porphyria.
CIC bioGUNE researchers participate in teaching tasks in the Medicine Degree at the University of Deusto, coordinating subjects in the first and second year.
Our Prion Diseases lab has been incorporated to the Infectious Diseases CIBER of Carlos III Health Institute.
CIC bioGUNE has kept its working capacity during the second year of the pandemic, establishing a specific plan that combines responsibility, safety, and focused research. Massive PCR and antibody analysis for all the members have been periodically carried out. Several collaborative projects on COVID-19, integrating 12 CIC bioGUNE research groups and different institutions and agents have continued to be developed during 2021. Seven publications on COVID-19-related topics have been presented along the year.
CIC bioGUNE keeps its position within the top 100 NPO/NGO Institutions worldwide (position 48th) in Life Sciences, according to Nature Index 2021.
CIC bioGUNE continues with its strategic plan to keep and reinforce the key infrastructures: new actions for acquisition of diverse equipment have been carried out, including the purchase of equipment for Biolayer Interferometry, Mosquito for X-Ray diffraction, fluorescence cytometer, MALDI TOF/TOF, HPLC-MS, together with the update of the animal facility. Moreover, CIC bioGUNE has purchased new spaces (980 m2) at Building 800 of the Bizkaia Technology Park. A proposal to renew one of the NMR consoles at the NMR platform (Singular Infrastructure of the State) has been granted.
Despite the pandemic, the introductory week (October 4-8) for the new Doctoral Candidates at CIC bioGUNE has been delivered in person with great success.
Competitive funding at CIC bioGUNE surpasses 14 M€, more than 2/3 of total funding. Private funding goes beyond 30% of total funding.
Outreach
Jeremy K. Nicholson (ANPC)
Óscar Millet
TV
Radio
Press
